PMID: 8989432Jan 1, 1997Paper

Human plasmatic apolipoprotein H binds human immunodeficiency virus type 1 and type 2 proteins

AIDS Research and Human Retroviruses
E StefasFrancisco Veas

Abstract

Apolipoprotein H (apo H), isolated from human plasma albumin solution, was shown to capture HIV-1-related antigens from antigen-positive sera (HIV-1 AG+) of AIDS patients, by using HIV-1-specific polyclonal antibodies. In an enzyme-linked immunosorbent assay and ligand blot and dot assays, apo H was able to bind recombinant retroviral HIV antigens, especially Gag proteins p18 of HIV-1, p26 of HIV-2, and Env gp160 of HIV-1. Binding was shown to be pH and NaCl dependent, with an optimum at acidic pH and low ionic strength. Specificity was demonstrated by saturation of this binding and inhibition either by homologous competition or by specific antisera. Binding was also observed in cell line-harvested viral proteins. The mechanism of this apo H-polyspecific binding is discussed in relation to conformational changes due to the influence of lipids or detergents.

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Citations

Oct 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Maria F PerdomoAnders Vahlne
Mar 13, 2009·Journal of Virology·Paula GodoyMarcelo López-Lastra
Sep 10, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Karl B McCannJoseph Bertolini
Nov 30, 2007·The Lancet Infectious Diseases·Jisun Oh, Robert A Hegele
Dec 24, 2009·Journal of Medical Virology·Pierluigi ToniuttoMario Pirisi
Jan 6, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Philippe SultanikUNKNOWN ANRS CO20-CUPIC
Jul 21, 2016·Journal of Microbiological Methods·Erin A AlmandLee-Ann Jaykus
Sep 28, 2015·Work : a Journal of Prevention, Assessment, and Rehabilitation·Paulo Roberto Veiga QuemeloEdgar Ramos Vieira

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