Human platelets effectively kill K-562 cells, a chronic myelogenic leukemia cell line, in vitro

Japanese Journal of Cancer Research : Gann
T SagawaM Okada

Abstract

The cytotoxic effect of isolated human platelets on leukemic cells has been examined in order to investigate the role of platelets in host defense systems. K-562 cells (a chronic myelogenic leukemia cell line) showed significant change in their morphology and were killed when they were incubated with platelets in serum-free medium for several hours at 37 degrees C, a condition where no killing of normal peripheral lymphocytes occurred. Some protease inhibitors inhibited the cytotoxicity of platelets against K-562 cells. Our results suggest that platelets may be involved in host defense against neoplasia and that certain proteases are implicated in the cytotoxic effect of platelets.

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Citations

Aug 1, 1996·Biulleten' eksperimental'noĭ biologii i meditsiny·T S GolubevaA R Tuguz
Feb 21, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·T S GolubevaA R Tuguz
Feb 1, 1996·Biulleten' eksperimental'noĭ biologii i meditsiny·A R TuguzS N Bykovskaia
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·P S FrenetteD D Wagner
Aug 1, 1997·Molecular Pathology : MP·D N Männel, G E Grau
Sep 1, 1992·British Journal of Haematology·M OkadaS Utsumi
Apr 1, 1997·FEBS Letters·T S GolubevaM V Kiselevsky
Aug 1, 1995·European Journal of Haematology·S GangarossaG Schilirò

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