Human platelets efficiently kill IgG-opsonized E. coli.

FEMS Immunology and Medical Microbiology
Anum H RiazRandall G Worth

Abstract

Platelets are known contributors of hemostasis but have recently been shown to be important in inflammation and infectious diseases. Moreover, thrombocytopenia is often observed in patients with sepsis. We previously reported that platelets actively phagocytosed IgG-coated latex beads. In this study, the capacity of human platelets to participate in host defense against bacterial infections was determined by assessing their ability to kill Escherichia coli. Washed human platelets were incubated with unopsonized or IgG-opsonized E. coli and evaluated for binding and killing of E. coli. We found that although both unopsonized and IgG-opsonized E. coli were associated with platelets, only IgG-opsonized E. coli were efficiently killed unless platelets were activated by a potent agonist. The bactericidal activity was dependent on FcγRIIA, was sensitive to cytochalasin D, but was not due to reactive oxygen metabolites. These data suggest that platelets may play an important role in protection against infection.

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Citations

Sep 12, 2014·Thrombosis and Haemostasis·Daniel DuerschmiedIngo Ahrens
May 23, 2012·Journal of Thrombosis and Haemostasis : JTH·N Cooper
Apr 23, 2015·Journal of Thrombosis and Haemostasis : JTH·M Arman, K Krauel
Apr 29, 2015·Platelets·Ana Lopez Alonso, Dermot Cox
Feb 17, 2017·Thrombosis and Haemostasis·Thomas J StockerChristian Schulz
Jan 20, 2018·Journal of Thrombosis and Haemostasis : JTH·R PalankarA Greinacher
Mar 28, 2018·Journal of Thrombosis and Haemostasis : JTH·M F HoylaertsP Verhamme
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Aug 6, 2019·Frontiers in Immunology·Alice AssingerJulie Rayes
Jul 1, 2020·Platelets·Genevieve MarcouxEric Boilard
Jun 6, 2018·Frontiers in Immunology·Aldana TrottaPaula Barrionuevo
Aug 11, 2020·Biomarker Research·Yufei ChenWen Gao
Mar 15, 2018·Frontiers in Medicine·Caroline SutFabrice Cognasse
Feb 5, 2021·Research and Practice in Thrombosis and Haemostasis·Oonagh Shannon
Feb 16, 2021·Journal of Thrombosis and Haemostasis : JTH·Pravin PatelSteven E McKenzie
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Aug 8, 2021·International Journal of Molecular Sciences·Théo EbermeyerHind Hamzeh-Cognasse
Jul 2, 2021·Dermatologic Therapy·Maysa T GhozGhada Fawzy Rezk Hassan

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