Human Polyclonal Antibodies Prevent Lethal Zika Virus Infection in Mice

Scientific Reports
Emilie BrancheSujan Shresta

Abstract

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that represents a major threat to global health. ZIKV infections in adults are generally asymptomatic or present with mild symptoms. However, recent outbreaks of ZIKV have revealed that it can cause Congenital Zika Syndrome in neonates and Guillain-Barré syndrome in adults. Currently, no ZIKV-specific vaccines or antiviral treatments are available. In this study, we tested the efficacy of convalescent plasma IgG hyperimmune product (ZIKV-IG) isolated from individuals with high neutralizing anti-ZIKV titers as a therapeutic candidate against ZIKV infection using a model of ZIKV infection in Ifnar1-/- mice. ZIKV-IG successfully protected mice from lethal ZIKV challenge. In particular, ZIKV-IG treatment at 24 hours after lethal ZIKV infection improved survival by reducing weight loss and tissue viral burden and improving clinical score. Additionally, ZIKV-IG eliminated ZIKV-induced tissue damage and inflammation in the brain and liver. These results indicate that ZIKV-IG is efficacious against ZIKV, suggesting this human polyclonal antibody is a viable candidate for further development as a treatment against human ZIKV infection.

References

Oct 1, 1979·The Journal of Infectious Diseases·Scott B Halstead
Mar 1, 1975·Annals of Tropical Medicine and Parasitology·D L MooreG E Kemp
Jan 1, 1976·The Journal of General Virology·J H WayG S Platt
Jan 1, 1988·The American Journal of Tropical Medicine and Hygiene·D S BurkeR M Scott
Jan 1, 1973·Archiv für die gesamte Virusforschung·A R FilipeH Rocha
May 1, 1969·The American Journal of Tropical Medicine and Hygiene·N J MarchetteA Rudnick
Jan 1, 1971·Archiv für die gesamte Virusforschung·T M BellH K Narang
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·J G Olson Triwibowo
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·E O Adekolu-John, A H Fagbami
Apr 1, 1983·Annals of Tropical Medicine and Parasitology·J G OlsonR See
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·M A DarwishF Omar
Aug 1, 1994·Antimicrobial Agents and Chemotherapy·A Casadevall, M D Scharff
Jan 7, 1998·Journal of Virology·G KunoC B Cropp
Jun 7, 2002·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·María G GuzmánScott B Halstead
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICK
Sep 1, 1963·Transactions of the Royal Society of Tropical Medicine and Hygiene·W L POND
Jul 1, 1964·Transactions of the Royal Society of Tropical Medicine and Hygiene·D I SIMPSON
Dec 24, 2003·Advances in Virus Research·Scott B Halstead
Aug 31, 2006·Annals of Internal Medicine·Thomas C LukeStephen L Hoffman
Jun 15, 2007·Nature Reviews. Microbiology·Stephen S WhiteheadBrian R Murphy
Dec 6, 2007·The Journal of Infectious Diseases·Ayato TakadaYoshihiro Kawaoka
Jun 12, 2009·The New England Journal of Medicine·Mark R DuffyEdward B Hayes
Oct 26, 1946·Journal of the American Medical Association·H E ALEXANDER, G LEIDY
Feb 7, 2012·Emerging Infectious Diseases·Vireak HeangMatthew R Kasper
Feb 12, 2014·PLoS Neglected Tropical Diseases·Gilda GrardEric Maurice Leroy
Apr 12, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·M BesnardDidier Musso
Apr 18, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Didier MussoJ Broult
May 27, 2014·Emerging Infectious Diseases·Van-Mai Cao-LormeauDidier Musso
Mar 12, 2015·Current Opinion in HIV and AIDS·Barney S Graham, Donna M Ambrosino
Feb 11, 2016·The New England Journal of Medicine·Jernej MlakarTatjana Avšič Županc
Feb 22, 2016·The Lancet Infectious Diseases·Guilherme Amaral CalvetAna Maria Bispo de Filippis
Mar 30, 2016·The American Journal of Tropical Medicine and Hygiene·Shannan L RossiScott C Weaver
Mar 31, 2016·The New England Journal of Medicine·Lyle R PetersenMargaret A Honein
Apr 14, 2016·Cell Host & Microbe·Helen M LazearMichael S Diamond
Apr 14, 2016·The New England Journal of Medicine·Sonja A RasmussenLyle R Petersen
Apr 19, 2016·Emerging Infectious Diseases·Robert LanciottiLeticia Del Carmen Castillo Signor
Apr 27, 2016·Lancet·Patrícia BrasilTom Solomon
May 6, 2016·PLoS Neglected Tropical Diseases·Stuart DowallRoger Hewson
May 24, 2016·Cell Host & Microbe·Alesha GrantAdolfo García-Sastre
Jun 23, 2016·Transfusion·Maria L Barjas-CastroMarcelo Addas-Carvalho
Jun 25, 2016·Nature·Giovanna Barba-SpaethFelix A Rey
Jun 25, 2016·Nature Immunology·Wanwisa DejnirattisaiGavin R Screaton
Jun 30, 2016·Lancet·Leonelo E Bautista, Ajay K Sethi
Jun 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Lalita PriyamvadaJens Wrammert
Jun 30, 2016·Nature·Rafael A LaroccaDan H Barouch
Jul 4, 2016·Lancet·Roosecelis Brasil MartinesSherif R Zaki
Aug 3, 2016·Cell Reports·Kimberly A DowdTheodore C Pierson
Aug 18, 2016·The New England Journal of Medicine·Iara J F MottaOrlando C Ferreira
Sep 11, 2016·Cell Reports·Jonathan J MinerRajendra S Apte
Nov 1, 2016·EMBO Reports·Anil KumarTom C Hobman
Nov 1, 2016·Nature·Jennifer GoveroMichael S Diamond
Dec 3, 2016·PLoS Neglected Tropical Diseases·Matthew T AliotaDavid H O'Connor
Dec 24, 2016·Cell Reports·William W TangSujan Shresta
Jan 13, 2017·Cell Host & Microbe·Annie Elong NgonoSujan Shresta
Mar 3, 2017·Bulletin of the World Health Organization·Erin SparrowSiranda Torvaldsen
Mar 23, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jucille do Amaral MenesesLindomar José Pena
Apr 7, 2017·JAMA : the Journal of the American Medical Association·Daniel LuceySabrina Sholts
Apr 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Qian ZhangAlessandro Vespignani
Sep 7, 2017·Scientific Reports·Jeffy GeorgeJoseph J Mattapallil
Nov 2, 2017·PLoS Neglected Tropical Diseases·Felipe J Colón-GonzálezIain R Lake
Dec 16, 2017·The Lancet Infectious Diseases·Thalia Velho Barreto de AraújoState Health Department of Pernambuco
Apr 12, 2018·The New England Journal of Medicine·Paul S MeadAlison F Hinckley
Jun 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Qiang DingAlexander Ploss
Aug 4, 2018·Nature Communications·Jose Angel Regla-NavaSujan Shresta
Aug 8, 2018·The Journal of Infectious Diseases·Satoru WatanabeSubhash G Vasudevan
Nov 16, 2018·Cell Host & Microbe·Angela M FowlerSujan Shresta
Jan 25, 2019·PLoS Pathogens·Annie Elong NgonoSujan Shresta

Citations

Jul 30, 2020·Journal of Leukocyte Biology·Tertuliano Alves Pereira NetoHelton da Costa Santiago

Methods Mentioned

BETA
Assay

Related Concepts

Brain
Tissue Damage
Flavivirus
Guillain-Barre Syndrome
Immunoglobulin Therapy
Inflammation
Liver
Laboratory mice
Culicidae
Plasma

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.