Human polymorphonuclear leukocyte response to Pseudomonas aeruginosa grown in biofilms.

Infection and Immunity
E T JensenN Høiby

Abstract

The interaction of human neutrophils with Pseudomonas aeruginosa biofilms was examined by using a chemiluminescence assay. The biofilms induced an oxidative burst response by polymorphonuclear leukocytes which was slow and only 25% of the response to planktonic bacteria. The reduced response to P. aeruginosa biofilms could play a role in the persistence of bacteria in chronic infections.

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