Human Pre-gastrulation Development

Current Topics in Developmental Biology
Sissy E Wamaitha, Kathy K Niakan

Abstract

Understanding the progression of early human embryonic development prior to implantation is of fundamental biological importance. Greater insights into early developmental events may lead to clinical improvements, not only via the establishment of novel stem cell models with increased potential or more physiological relevance, but also by uncovering some underlying causes of infertility, miscarriages, and developmental disorders. The majority of human embryos available for study are those donated to research once they are surplus to family building following in vitro fertilization, though in some countries it is also possible to create embryos using donated gametes. As human embryo development is surprisingly inefficient, with only 40% reaching the blastocyst stage in vitro (French, Sabanegh, Goldfarb, & Desai, 2010; Gardner, Lane, Stevens, Schlenker, & Schoolcraft, 2000), many embryos may not develop to a stage suitable for study. Where legally permitted, the oversight of human embryo research is subject to either ethics approval from a local institutional review board (i.e., China and the United States) or both a national regulator as well as a regional research ethics committee (i.e., the United Kingdom). The study of human ...Continue Reading

Citations

Mar 19, 2020·Biomolecules·Susana M Chuva de Sousa LopesGudrun Valdimarsdottir
Nov 21, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·Jonas L FowlerKyle M Loh
Jul 28, 2020·Human Reproduction Update·Ana M Pereira DaoudBjörn Heindryckx
Jul 25, 2018·Nature Cell Biology·Marta N Shahbazi, Magdalena Zernicka-Goetz
Jan 28, 2021·Seminars in Cell & Developmental Biology·Vallari ShuklaEva R Hoffmann
Mar 17, 2021·Development·Grace V HancockAmander T Clark
Jul 14, 2021·Seminars in Cell & Developmental Biology·Julie Firmin, Jean-Léon Maître
Aug 18, 2021·ELife·Kirsty Ml MackinlayMagdalena Zernicka-Goetz
Aug 28, 2021·Nature Communications·Ran YangKenneth R Chien
Sep 23, 2021·Nature Communications·Berna SozenMagdalena Zernicka-Goetz
Oct 12, 2021·Cells & Development·Edgar Herrera-Delgado, Jean-Léon Maître

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