PMID: 7061225Feb 1, 1982Paper

Human prealbumin fraction: effects on cell-mediated immunity and tumor rejection

Immunopharmacology
K H LeungE Mihich

Abstract

The effect of human prealbumin fraction as allogeneic cell-mediated immunity in primary sensitization cultures of murine spleen cells was studied by 3H-thymidine uptake and specific 51Cr release assays. Prealbumin caused a dose-dependent augmentation of these responses. Human serum albumin, bovine serum albumin, and calf-thymosin fraction 5 had little effect. Prealbumin was active when added on day 0 or 1 but not thereafter. Prealbumin added to effector cells from immunized mice did not change their lytic activity. Prealbumin, but not human serum albumin or thymosin fraction 5, augmented secondary cell-mediated immunity in culture after primary immunization in mice. A slow growing mammary tumor line, which originated as a spontaneous mammary tumor in a DBA/2 HaDD breeder mouse, initially grows in 100% of DBA/2J mice but is then rejected in 10-20% of them. When prealbumin (59 microgram/day) was given subcutaneously for 2 weeks to DBA/2J mice and the tumor implanted 2 weeks later. 78% of the mice rejected the tumor and were then resistant to a rechallenge.

References

Jan 1, 1979·Annals of the New York Academy of Sciences·J F BachJ M Pléau
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P BurtonA WHITE
Jan 1, 1979·Annals of the New York Academy of Sciences·A WHITE, P Burton
Nov 1, 1978·Transplantation·R M FergusonR L Simmons
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J F BachA WHITE
Sep 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·A L GOLDSTEINA WHITE
Feb 1, 1980·European Journal of Immunology·M DardenneJ F Bach
Nov 1, 1962·The Journal of Experimental Medicine·R A GOODB W PAPERMASTER
Apr 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·J J KLEINA WHITE

Citations

Jan 1, 1983·International Journal of Immunopharmacology·M J EhrkeE Mihich
Jan 1, 1985·International Journal of Immunopharmacology·P BurtonA WHITE
May 19, 2019·The Clinical Respiratory Journal·Biyun LiChen Wang

Related Concepts

Metazoa
Chromium Radioisotopes
Graft Rejection
Cellular Immune Response
Mice, Inbred C57BL
Mice, Inbred DBA
Neoplasm Transplantation
Prealbumin
Plasma Albumin
Spleen

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