PMID: 7061225Feb 1, 1982Paper

Human prealbumin fraction: effects on cell-mediated immunity and tumor rejection

K H LeungE Mihich


The effect of human prealbumin fraction as allogeneic cell-mediated immunity in primary sensitization cultures of murine spleen cells was studied by 3H-thymidine uptake and specific 51Cr release assays. Prealbumin caused a dose-dependent augmentation of these responses. Human serum albumin, bovine serum albumin, and calf-thymosin fraction 5 had little effect. Prealbumin was active when added on day 0 or 1 but not thereafter. Prealbumin added to effector cells from immunized mice did not change their lytic activity. Prealbumin, but not human serum albumin or thymosin fraction 5, augmented secondary cell-mediated immunity in culture after primary immunization in mice. A slow growing mammary tumor line, which originated as a spontaneous mammary tumor in a DBA/2 HaDD breeder mouse, initially grows in 100% of DBA/2J mice but is then rejected in 10-20% of them. When prealbumin (59 microgram/day) was given subcutaneously for 2 weeks to DBA/2J mice and the tumor implanted 2 weeks later. 78% of the mice rejected the tumor and were then resistant to a rechallenge.


Jan 1, 1979·Annals of the New York Academy of Sciences·J F BachJ M Pléau
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Nov 1, 1978·Transplantation·R M FergusonR L Simmons
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J F BachA WHITE
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Jan 1, 1983·International Journal of Immunopharmacology·M J EhrkeE Mihich
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May 19, 2019·The Clinical Respiratory Journal·Biyun LiChen Wang

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