Human pregnancy is accompanied by modifications in B cell development and immunoglobulin profile

Journal of Reproductive Immunology
K B ZieglerF Jensen

Abstract

Though human pregnancy success has been classically linked with a shift into a Th2 immunoglobulin producing cell response, a clear picture concerning B cell development and immunoglobulin profile during human pregnancy is missing. We analyzed in this work the dynamic of different B cell populations in peripheral blood of pregnant women on the first, second and third trimester of pregnancy. As control, age-matched non-pregnant fertile women were included. Additionally, we quantified the levels of immunoglobulin (IgG1, IgG2, IgG3, IgG4, IgM, IgA and IgE) in the serum of pregnant and non-pregnant women. We observed a significant decrease in the percentages of transitional B cells in peripheral blood of pregnant women as compared to non-pregnant control women. Besides, percentages of naïve as well as switched and non-switched memory B cells in peripheral blood of pregnant women were similar to those in non-pregnant control women. Interestingly, although we did not observe differences in the activation status of B cells as well as in the percentages of plasma cells between pregnant and non-pregnant women, we observed significantly higher levels of IgM, IgA, IgG3, more likely natural antibodies, as well IgG4 in serum of pregnant wome...Continue Reading

Citations

Jan 10, 2019·American Journal of Reproductive Immunology : AJRI·Jorge LimaMaria Leandro
Feb 16, 2019·American Journal of Reproductive Immunology : AJRI·Yaozhu LengNardhy Gomez-Lopez
Jan 11, 2020·Frontiers in Immunology·Ruth Marian Guzman-GenuinoKerrilyn R Diener
Nov 3, 2020·Frontiers in Immunology·Bahaa Abu-RayaPascal M Lavoie

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