Human pro- and anti-inflammatory cytokine patterns induced by Streptococcus pyogenes erythrogenic (pyrogenic) exotoxin A and C superantigens.

Infection and Immunity
H Müller-AloufJ M Cavaillon

Abstract

The superantigenic streptococcal erythrogenic toxins A and C (ETA/SPEA and ETC/SPEC) elicit the production by human peripheral blood mononuclear cells of substantial amounts of Th1-derived cytokines (interleukin-2 [IL-2] and gamma interferon) as well as anti-inflammatory cytokines (IL-10 and IL-1 receptor antagonist). In contrast, very low levels of IL-4 and no alpha interferon were induced. The production of these cytokines after stimulation with Streptococcus pyogenes heat-killed bacteria and lipopolysaccharide from gram negative bacteria differed qualitatively and quantitatively from that elicited by the superantigens.

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Citations

Aug 31, 2001·Clinical and Diagnostic Laboratory Immunology·L M PlitnickE J Gosselin
Oct 4, 2015·Cellular Microbiology·Timothy C BarnettMark J Walker
Jul 27, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Thomas ProftJohn D Fraser
May 3, 2018·Pathogens and Disease·Jean-Marc Cavaillon
May 26, 1999·Infectious Disease Clinics of North America·J BannanJ B Zabriskie

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