Human prolactin receptors are insensitive to mouse prolactin: implications for xenotransplant modeling of human breast cancer in mice

The Journal of Endocrinology
Fransiscus E UtamaHallgeir Rui

Abstract

Experimental testing of growth, metastatic progression and drug responsiveness of human breast cancer in vivo is performed in immunodeficient mice. Drug candidates need to show promise against human breast cancer in mice before being allowed into clinical trials. Breast cancer growth is under endocrine control by ovarian steroids and the pituitary peptide hormone prolactin. While it is recognized that the most relevant biologic effects of prolactin are achieved with prolactin from the matching species, the biologic efficacy of mouse prolactin for human prolactin receptors has not been recorded. Thus, it is unclear whether the mouse endocrine environment adequately reflects the hormonal environment in breast cancer patients with regard to prolactin. We now show both recombinant and natural pituitary-derived mouse prolactin to be a poor agonist for human prolactin receptors. Mouse prolactin failed to induce human prolactin receptor-mediated biologic responses of cell clustering, proliferation, gene induction and signal transduction, including activation of Stat5, Stat3, Erk1/2 and Akt pathways. Consistent data were derived from human breast cancer lines T-47D, MCF-7 and ZR-75.1, as well as human prolactin receptor-transfected COS...Continue Reading

Citations

Apr 17, 2013·Biotechnology and Applied Biochemistry·Miriam F SuzukiCarlos R J Soares
Nov 14, 2008·Cell and Tissue Research·Aaron M MarshallNelson D Horseman
Jan 30, 2008·Journal of Mammary Gland Biology and Neoplasia·Kay-Uwe Wagner, Hallgeir Rui
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Dec 28, 2016·Cancer Metastasis Reviews·Lacey E DobroleckiMichael T Lewis
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Jun 3, 2021·Cancers·Dana C BorcherdingNira Ben-Jonathan
Sep 8, 2021·Cancer Metastasis Reviews·Rayane DennaouiKay-Uwe Wagner
Jul 6, 2014·Cold Spring Harbor Protocols·Leonard D ShultzDale L Greiner

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