Abstract
Experimental testing of growth, metastatic progression and drug responsiveness of human breast cancer in vivo is performed in immunodeficient mice. Drug candidates need to show promise against human breast cancer in mice before being allowed into clinical trials. Breast cancer growth is under endocrine control by ovarian steroids and the pituitary peptide hormone prolactin. While it is recognized that the most relevant biologic effects of prolactin are achieved with prolactin from the matching species, the biologic efficacy of mouse prolactin for human prolactin receptors has not been recorded. Thus, it is unclear whether the mouse endocrine environment adequately reflects the hormonal environment in breast cancer patients with regard to prolactin. We now show both recombinant and natural pituitary-derived mouse prolactin to be a poor agonist for human prolactin receptors. Mouse prolactin failed to induce human prolactin receptor-mediated biologic responses of cell clustering, proliferation, gene induction and signal transduction, including activation of Stat5, Stat3, Erk1/2 and Akt pathways. Consistent data were derived from human breast cancer lines T-47D, MCF-7 and ZR-75.1, as well as human prolactin receptor-transfected COS...Continue Reading
Citations
Apr 20, 2016·The Oncologist·Neeraj AgarwalMohamed Elmeliegy
Apr 17, 2013·Biotechnology and Applied Biochemistry·Miriam F SuzukiCarlos R J Soares
Jun 7, 2007·Molecular Endocrinology·Lynn M NeilsonHallgeir Rui
May 24, 2007·Molecular Endocrinology·Kazuhito SakamotoKay-Uwe Wagner
Mar 3, 2015·Endocrinology·Andrzej Bartke, John J Kopchick
Nov 28, 2008·Endocrinology·Feng FangCharles V Clevenger
Sep 14, 2013·Endocrinology·Heather R ChristensenKaren A Gregerson
Oct 24, 2007·Breast Cancer Research and Treatment·Michele L ScottiWen Y Chen
Nov 14, 2008·Cell and Tissue Research·Aaron M MarshallNelson D Horseman
Jan 30, 2008·Journal of Mammary Gland Biology and Neoplasia·Kay-Uwe Wagner, Hallgeir Rui
May 1, 2007·Thyroid : Official Journal of the American Thyroid Association·Giuseppe RongaDiego Russo
Dec 7, 2007·Endocrine Reviews·Nira Ben-JonathanElizabeth W LaPensee
Sep 6, 2013·Breast Cancer Research : BCR·Ning YangHallgeir Rui
Feb 9, 2018·Endocrinology·Nelly SaberTimothy J Kieffer
Nov 22, 2008·Endocrinology·Fransiscus E UtamaHallgeir Rui
Apr 9, 2008·Breast Cancer Research and Treatment·Katai J NkhataMargot P Cleary
Dec 28, 2016·Cancer Metastasis Reviews·Lacey E DobroleckiMichael T Lewis
Mar 1, 2012·Molecular Oncology·Michele De Palma, Douglas Hanahan
Oct 7, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Vincent GoffinPaul A Kelly
Jun 6, 2013·Cancer Research·Xiaomei ZhangMichael T Lewis
Aug 12, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thai H TranHallgeir Rui
Mar 12, 2009·Cancer Research·Alexandr PlotnikovSerge Y Fuchs
Dec 29, 2012·Molecular Cancer Therapeutics·Jason S DamianoJudith A Abraham
Apr 6, 2017·Molecular Cancer Therapeutics·Marcus P KellyJessica R Kirshner
Jun 3, 2021·Cancers·Dana C BorcherdingNira Ben-Jonathan
Sep 16, 2021·Science Advances·Yunguang SunHallgeir Rui
Sep 8, 2021·Cancer Metastasis Reviews·Rayane DennaouiKay-Uwe Wagner
Jul 6, 2014·Cold Spring Harbor Protocols·Leonard D ShultzDale L Greiner