PMID: 7279800Jan 1, 1980

Human prostatic adenocarcinoma: some characteristics of a serially transplantable line in nude mice (PC 82)

The Prostate
W HoehnP Hermanek

Abstract

Transplantation of tissue from a cribriform human prostatic carcinoma resulted in a serially transplantable tumor line in nude mice, PC 82. During 2 1/2 years the tumor has not changed its histological appearance and remained a moderately differentiated adenocarcinoma. The cells contain large amounts of prostatic acid phosphatase. It has a slow rate of growth and regresses after castration and estrogen treatment. This preliminary information suggests that the PC 82 tumor line may be suitable model for hormone-dependent human prostatic cancer.

References

Dec 5, 2000·The Prostate·D R ChesireW B Isaacs
Oct 18, 2002·International Journal of Cancer. Journal International Du Cancer·Paul C M S VerhagenJ Trapman
Nov 1, 1988·Cancer Metastasis Reviews·J MatternM Volm
Jan 1, 1984·Cancer Metastasis Reviews·F E Sharkey, J Fogh
Jul 10, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ketao JinGuangliang Li
Aug 1, 1988·Cancer Genetics and Cytogenetics·J J KönigF H Schröder
Nov 25, 1987·Biochimica Et Biophysica Acta·J L Ware
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·J TrapmanA O Brinkmann
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·Wytske van WeerdenF H Schröder
Jul 1, 1996·Urologic Oncology·Wytske van Weerden, G J van Steenbrugge
Apr 7, 2010·Asian Journal of Andrology·Lluis A Lopez-Barcons
May 13, 2014·Advanced Drug Delivery Reviews·Stuart J EllemGail P Risbridger
Oct 31, 2009·Journal of Cellular and Molecular Medicine·Lluis-A Lopez-Barcons
Jan 12, 2005·The Journal of Urology·R E Sobel, M D Sadar
Jul 1, 1987·European Journal of Cancer & Clinical Oncology·M R SchneiderF Sinowatz
Apr 1, 1992·Human Pathology·A A Sandberg
Nov 15, 1989·International Journal of Cancer. Journal International Du Cancer·A R BrothmanD J Merchant
Sep 15, 1983·International Journal of Cancer. Journal International Du Cancer·S A MetcalfeB T Hill

Citations

Jun 1, 1976·Journal of the National Cancer Institute·Y ShimosatoT Nomura
Mar 1, 1978·Journal of the National Cancer Institute·S D GrahamD F Paulson
Mar 15, 1978·International Journal of Cancer. Journal International Du Cancer·K R StoneD F Paulson
Jan 9, 1976·Science·W A Nelson-Rees, R R Flandermeyer
Dec 1, 1973·Journal of Virology·Y M CentifantoS L Deardourff

Related Concepts

Prostatic Neoplasms
Acid Phosphatase
Estradiol, (16 alpha,17 beta)-Isomer
House mice
Prostate Carcinoma
ACPP gene
Cell Differentiation Process
Adenocarcinoma
Cell Division Phases
Electron Microscopy

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