Human Protein Atlas of redox systems - what can be learnt?

Biochimica Et Biophysica Acta
Pascal Dammeyer, Elias S J Arnér

Abstract

High-throughput screening projects are popular approaches to yield a vast amount of information amenable for database mining and "hypothesis generation". The keys to success for these approaches depend upon the quality of primary data, choice of algorithms for data analyses, solidity in data annotations and the general usefulness of the results. A large initiative aimed at mapping the expression of all human proteins is the Human Protein Atlas (www.proteinatlas.org), encompassing immunohistochemical analyses of human tissues utilizing antibodies raised against a large number of human proteins. Here, we wished to probe what could be learnt from this atlas using a manual in-depth analysis of the results regarding the expression of key proteins in the human glutathione and thioredoxin systems. The freely available on-line data of immunohistochemical analyses for selected human redox proteins within the Human Protein Atlas were here analyzed, provided that reasonably solid data existed for the antibodies that were employed. This included tissue expression data for thioredoxin 1 (Trx1), Trx2, thioredoxin reductase 1 (TrxR1), TrxR2, glutathione reductase (GR), glucose 6-phosphate dehydrogenase (G6PD), γ-glutamyl cysteinyl synthase (g...Continue Reading

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