Human protein interaction networks across tissues and diseases

Frontiers in Genetics
Esti Yeger-Lotem, Roded Sharan

Abstract

Protein interaction networks are an important framework for studying protein function, cellular processes, and genotype-to-phenotype relationships. While our view of the human interaction network is constantly expanding, less is known about networks that form in biologically important contexts such as within distinct tissues or in disease conditions. Here we review efforts to characterize these networks and to harness them to gain insights into the molecular mechanisms underlying human disease.

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Methods Mentioned

BETA
two-hybrid
co-immunoprecipitation
affinity purification

Software Mentioned

MINT
IntAct
DIP
GTEx
BodyMap

Related Concepts

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