Oct 4, 2007

Human psychoneuroimmunology: 20 years of discovery

Brain, Behavior, and Immunity
Michael R Irwin


An important component of psychoneuroimmunology research is to reveal the myriad ways that behaviors and health are inter-related, with a focus on the immunological mechanisms that underlie these interactions. Research in human psychoneuroimmunology has shown that immunoregulatory processes are an integral part of a complex network of adaptive responses. As such, this review provides a perspective from our laboratory over the last 20 years to define the inter-relationships between behavior and immunity; to identify the hypothalamic pituitary adrenal (HPA) and autonomic mechanisms that link the central nervous system and immune responses; to examine the clinical implications of immune alterations during depression or life stress on inflammatory and infectious disease risk; and to explore the reciprocal role of immune mediators on behavior in humans.

  • References62
  • Citations73

Mentioned in this Paper

Autonomic Nervous System Disorders
Immune Response
Biochemical Pathway
Immune System
Lymphocyte Proliferation
Morbidity Aspects
Decreased Immunologic Activity [PE]
TLR4 gene
Interleukin 6 Receptor

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