Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil

The Journal of Nervous and Mental Disease
Charles S GrobK B Boone

Abstract

A multinational, collaborative, biomedical investigation of the effects of hoasca (ayahuasca), a potent concoction of plant hallucinogens, was conducted in the Brazilian Amazon during the summer of 1993. This report describes the psychological assessment of 15 long-term members of a syncretic church that utilizes hoasca as a legal, psychoactive sacrament as well as 15 matched controls with no prior history of hoasca ingestion. Measures administered to both groups included structured psychiatric diagnostic interviews, personality testing, and neuropsychological evaluation. Phenomenological assessment of the altered state experience as well as semistructured and open-ended life story interviews were conducted with the long-term use hoasca group, but not the hoasca-naive control group. Salient findings included the remission of psychopathology following the initiation of hoasca use along with no evidence of personality or cognitive deterioration. Overall assessment revealed high functional status. Implications of this unusual phenomenon and need for further investigation are discussed.

References

Dec 1, 1991·Psychological Reports·C R CloningerD M Svrakic
Jan 1, 1989·Journal of Psychoactive Drugs·G Bravo, C Grob
Oct 1, 1984·Journal of Psychoactive Drugs·D J McKenna, G H Towers
Mar 1, 1993·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·M MajUNKNOWN World Health Organization, Division of Mental Health/Global Programme on AIDS

❮ Previous
Next ❯

Citations

Feb 6, 2004·Pharmacology & Therapeutics·David E Nichols
Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·E A Carlini
Apr 11, 2001·Drug and Alcohol Dependence·J RibaM J Barbanoj
Jul 3, 1998·Drug and Alcohol Dependence·B GrellaR A Glennon
Mar 18, 1999·Drug and Alcohol Dependence·J H Halpern, H G Pope
Jun 18, 1999·Drug and Alcohol Dependence·C S Freedland, R S Mansbach
Jul 15, 1999·Journal of Ethnopharmacology·J C CallawayD C Mash
Jan 30, 1999·Journal of Psychoactive Drugs·C S GrobM Mangini
Jan 30, 1999·Journal of Psychoactive Drugs·G H Shepard
Jan 30, 1999·Journal of Psychoactive Drugs·R Metzner
Nov 4, 2000·Journal of Psychoactive Drugs·M P Bogenschutz
Sep 10, 2005·Journal of Psychoactive Drugs·Marlene Dobkin de Rios, Charles S Grob
Sep 10, 2005·Journal of Psychoactive Drugs·Evelyn Doering-SilveiraDartiu X Da Silveira
Sep 10, 2005·Journal of Psychoactive Drugs·Dartiu Xavier Da SilveiraEvelyn Doering-Silveira
Sep 10, 2005·Journal of Psychoactive Drugs·Evelyn Doering-SilveiraDartiu Xavier Da Silveira
Sep 10, 2005·Journal of Psychoactive Drugs·J C Callaway
Sep 10, 2005·Journal of Psychoactive Drugs·David E StuckeyLuis Eduardo Luna
Sep 10, 2005·Journal of Psychoactive Drugs·Dennis J McKenna
Aug 27, 2009·Journal of Psychoactive Drugs·Stephen TrichterStanley Krippner
Dec 17, 2009·Journal of Psychoactive Drugs·Paulo Cesar Ribeiro BarbosaRick Strassman
May 11, 2013·Journal of Psychoactive Drugs·Rafael Guimarães dos Santos
Jul 3, 2008·Journal of Psychopharmacology·Mw JohnsonRr Griffiths
Oct 1, 2011·Journal of Psychopharmacology·Katherine A MacLeanRoland R Griffiths
Mar 20, 2010·Journal of Psychoactive Drugs·Anette KjellgrenTorsten Norlander
Jul 25, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daiane Martins, Cecilia Veronica Nunez
Jan 20, 2009·The American Journal of Drug and Alcohol Abuse·Lin LuThomas R Kosten
Feb 5, 2016·Pharmacological Reviews·David E Nichols
Mar 31, 2012·The International Journal on Drug Policy·Brian T AndersonDennis McKenna
Apr 1, 1998·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·N S DonN R Farnsworth
Mar 15, 2016·Frontiers in Pharmacology·Ede FrecskaMichael Winkelman
Oct 31, 2015·Journal of Psychoactive Drugs·Veronika Kavenská, Hana Simonová
Jul 22, 2008·The International Journal on Drug Policy·Kenneth W Tupper
Dec 8, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Rafael Guimarães Dos Santos
Jul 5, 2012·Drug Testing and Analysis·Paulo Cesar Ribeiro BarbosaRick J Strassman
Apr 15, 2014·The American Journal on Addictions·Hong-Qiang SunThomas R Kosten
May 28, 2004·Pharmacology & Therapeutics·John H Halpern
Aug 24, 2013·The American Journal of Drug and Alcohol Abuse·Brittany Vasae Burdick, Bryon Adinoff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.