Human rabies in India: an audit from a rabies diagnostic laboratory

Tropical Medicine & International Health : TM & IH
Reeta Subramaniam ManiShampur N Madhusudana

Abstract

Rabies, an acute progressive encephalomyelitis, continues to be a serious public health problem in India and many other countries in Asia and Africa. The low level of commitment to rabies control is partly attributable to challenges in laboratory diagnosis and lack of adequate surveillance to indicate the disease burden. A laboratory audit of human rabies cases was undertaken to disseminate information on the clinical, demographic, prophylactic and most importantly the laboratory diagnostic aspects of rabies. A retrospective analysis of all clinically suspected human rabies cases, whose samples were received at a rabies diagnostic laboratory in South India in the last 3 years, was performed. Clinical and demographic details of patients were obtained. The clinical samples included cerebrospinal fluid (CSF), serum, saliva and nuchal skin biopsy collected antemortem, and brain tissue obtained post-mortem. Various laboratory tests were performed for diagnosis. Clinical samples from 128 patients with suspected rabies, from 11 states in India, were received for diagnostic confirmation. About 94% of the victims reported dog-bites, more than a third of them were children and most of the victims did not receive adequate post-exposure pr...Continue Reading

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Citations

Jan 23, 2016·Tropical Medicine & International Health : TM & IH·M J Warrell
Jun 22, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Anita MahadevanSusarala K Shankar
Jul 29, 2016·PLoS Neglected Tropical Diseases·Reeta Subramaniam Mani
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Mar 18, 2021·Epidemiologia E Serviços De Saúde : Revista Do Sistema Unico De Saúde Do Brasil·Naylê Francelino Holanda DuarteJorg Heukelbach

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