Human rabies transmitted by vampire bats: antigenic and genetic characterization of rabies virus isolates from the Amazon region (Brazil and Ecuador)

Virus Research
Juliana Galera CastilhoIvanete Kotait

Abstract

Since 2004, the main transmitter of human rabies in Latin America has been the vampire bat (Desmodus rotundus). Based on the nucleoprotein of the rabies virus (RV), we analyzed antigenic and genetic profiles of isolates from 29 samples taken from humans living in different areas of the Amazon region. Two isolates were from Ecuador and 27 from the Northern and Northeastern regions of Brazil, which were obtained during outbreaks in various municipalities in the states of Pará and Maranhão in the years 2004 and 2005. The partial N gene (nt 104-1477) of the 29 isolates was sequenced, and the sequences were used to build a neighbor-joining tree with the Kimura-2 parameter model. All 29 human RV isolates were identified as belonging to antigenic variant 3 (AgV3) and were genetically grouped into the D. rotundus cluster, which was divided into two subclusters (A and B), subcluster A in turn being divided into four genetic groups (A1, A2, A3 and A4). Genetic and molecular markers characterizing these genetic lineages were also identified. The results of this study show that the isolates belong to the same rabies cycle as that of the vampire bat D. rotundus. However, the division of clusters within the lineage associated with D. rotundu...Continue Reading

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Citations

Jan 16, 2013·Virus Research·Helena GuarinoIvanete Kotait
May 4, 2011·Journal of Virological Methods·Camila ZanlucaCarlos Roberto Zanetti
Aug 1, 2014·PLoS Neglected Tropical Diseases·James A EllisonCharles E Rupprecht
Sep 28, 2016·Archives of Virology·Débora Nunes de SouzaJuliana Galera Castilho Kawai
Sep 24, 2015·PloS One·Monica Cartelle GestalMarcelo Cevallos
Feb 5, 2015·Revista Do Instituto De Medicina Tropical De São Paulo·Luis E EscobarGonzalo Medina-Vogel
Oct 29, 2011·Archives of Virology·Luzia Helena QueirozEdison Luiz Durigon
Jan 20, 2020·Virus Genes·Marcélia Emanuele S FernandesHelena B C R Batista

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