Human-relevant preclinical in vitro models for studying hepatobiliary development and liver diseases using induced pluripotent stem cells.

Experimental Biology and Medicine
Pooja ChaudhariYoon-Young Jang

Abstract

In this review, we address the potential of human-induced pluripotent stem cell-based hepatobiliary differentiation technology as a means to study human liver development and cell fate determination, and to model liver diseases in an effort to develop a new human-relevant preclinical platform for drug development.

References

Oct 13, 2000·Regulatory Toxicology and Pharmacology : RTP·H OlsonA Heller
Mar 6, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Alessia OmenettiAnna Mae Diehl
Apr 6, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Gebran Abboud, Neil Kaplowitz
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Youngmi JungAnna Mae Diehl
Jan 16, 2008·The British Journal of Surgery·P GeorgievP-A Clavien
Dec 27, 2008·Journal of Hepato-biliary-pancreatic Surgery·Masahiro ItoIra J Fox
Dec 25, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hisashi MoriguchiChifumi Sato
Feb 18, 2010·Developmental Cell·Karim Si-TayebStephen A Duncan
May 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hua LiuYoon-Young Jang
Aug 27, 2010·The Journal of Clinical Investigation·S Tamir RashidLudovic Vallier
Apr 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alessia OmenettiPeter F Whitington
May 13, 2011·Science Translational Medicine·Hua LiuYoon-Young Jang
Nov 19, 2011·Biochemical and Biophysical Research Communications·Takeshi YoshidaKiyohito Yagi
Dec 6, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yue YuScott L Nyberg
Aug 14, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Haibo BaiRobert A Anders
Jan 18, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Su Mi ChoiYoon-Young Jang
Jun 13, 2013·Stem Cells Translational Medicine·Claire N MedineDavid C Hay
Nov 16, 2013·Assay and Drug Development Technologies·Oksana SirenkoEvan F Cromwell
Jan 11, 2014·Nature Biotechnology·Michael HayJesse Rosenthal
Jan 21, 2014·Biotechnology Advances·R E SchwartzS N Bhatia
Jun 7, 2014·Cell·Dean YimlamaiFernando D Camargo
Nov 25, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Cory SmithZhaohui Ye
Dec 19, 2014·Methods in Molecular Biology·Lipeng TianYoon-Young Jang
Feb 11, 2015·Stem Cell Reports·Shengyong NgSangeeta N Bhatia
Jun 18, 2015·Development·Miriam GordilloValerie Gouon-Evans
Jun 22, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Quy NguyenHaibo Bai
Jul 15, 2015·Nature Biotechnology·Mina OgawaAnand Ghanekar
Aug 15, 2015·Cellular and Molecular Gastroenterology and Hepatology·Luca MaroniGianfranco Alpini
Sep 10, 2015·Journal of Autoimmunity·James Neuberger
Nov 5, 2014·Cell Medicine·Yue YuScott L Nyberg
May 21, 2016·Nature Reviews. Drug Discovery·Katarzyna SmietanaMartin Møller
Aug 30, 2016·International Journal of Biological Sciences·Lipeng TianYoon-Young Jang
Dec 23, 2016·Gastroenterology·Sachin H PatelDean Yimlamai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Stem Cells & Regenerative Medicine
Hm AejazCm Habibullah
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Luke Ad Bury, Anthony Wynshaw-Boris
Laboratory Investigation; a Journal of Technical Methods and Pathology
Thiago M De AssuncaoRobert C Huebert
© 2022 Meta ULC. All rights reserved