Human renal allograft rejection is predicted by serial determinations of antibody-dependent cellular cytotoxicity

Transplantation
L J DumbleP Kincaid-Smith

Abstract

The early recognition and prompt treatment of rejection may minimise damage to renal allografts. Preliminary studies showed whole blood effector cell function in a constant antibody-dependent cellular cytotoxicity (ADCC) assay system to be suppressed in recipients with stable renal function. To investigate the possible role of ADCC in the rejection process, serial estimates were performed in 29 consecutive recipients of cadaveric kidneys. The generation of ADCC, as measured in vitro, preceded the biochemical confirmation of an impending rejection episode by 3 to 5 days for 31 of 33 episodes experienced by 23 recipients. Statistical analysis (X2) demonstrated a highly significant correlation between ADCC generation as measured in vitro and subsequent episodes of graft rejection. In contrast, six recipients who did not experience rejection episodes during the first 3 months postgrafting showed no evidence of ADCC activity. Thus, ADCC may be used to identify rejection earlier than has previously been possible.

Citations

Jul 1, 1982·Journal of Clinical Immunology·S B Krantz, E N Dessypris
Jan 1, 1981·Journal of Immunological Methods·I M MacDonaldG J Clunie
Nov 20, 1997·Transplantation Proceedings·M A BakrM A Ghoneim
Dec 1, 1982·Clinical Immunology and Immunopathology·T M EllisT Mohanakumar
Sep 1, 1981·Scandinavian Journal of Haematology·M JakóbisiakM Sosnowska

Related Concepts

Krebiozen
Microcytotoxicity Test
Immunologic Tumoricidal Activities
Graft Rejection
Differential White Blood Cell Count Procedure
Transplantation, Homologous
Kidney Transplantation

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