Human renal cancer stem cells

Cancer Letters
Benedetta BussolatiGiovanni Camussi

Abstract

Cancer stem cells (CSCs), isolated in renal carcinomas, exhibit tumor-initiating capabilities and pluripotency. No specific CSC markers have been identified so far; therefore, their characterization is mainly based on functional studies. As they are resistant to chemo and radio therapy, renal CSCs may have a relevant role in tumor establishment, progression, and recurrence. CSCs were also shown to contribute to intra-tumor vasculogenesis through an endothelial differentiation and to favor the generation of the pre-metastatic niche through the release of exosomes/microvesicles.

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Citations

Apr 15, 2014·International Journal of Oncology·Jürgen Dittmer, Benjamin Leyh
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Apr 25, 2019·International Journal of Molecular Sciences·Cristina GrangeBenedetta Bussolati

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