PMID: 3773052Nov 1, 1986Paper

Human respiratory syncytial virus glycoprotein G expressed from a recombinant vaccinia virus vector protects mice against live-virus challenge

Journal of Virology
E J StottG W Wertz

Abstract

Recombinant vaccinia virus vectors were constructed which expressed the major surface glycoprotein G of human respiratory syncytial (RS) virus. The biological activity of the G protein expressed from these vectors was assayed. Inoculation of rabbits with live recombinant virus induced high titers of antibody which specifically immunoprecipitated RS virus G protein and was capable of neutralizing RS virus infectivity. Immunization of mice by either the intranasal or the intraperitoneal route with recombinant virus that expressed only the G protein resulted in complete protection of the lower respiratory tract upon subsequent challenge with live RS virus.

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Citations

Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H BelangerV Yusibov
Jan 1, 1988·Avian Pathology : Journal of the W.V.P.A·D Cavanagh
Sep 1, 1992·European Journal of Pediatrics·M L Everard, A D Milner
Oct 1, 1988·Journal of Medical Virology·B S GrahamD T Karzon
Sep 28, 2006·Reviews in Medical Virology·S van Drunen Littel-van den HurkJ Kovacs-Nolan
Jan 1, 1990·Archives of Virology·T G Kimman, F Westenbrink
Jul 16, 2005·Expert Opinion on Biological Therapy·Martin Cranage, Geraldine Taylor
Sep 15, 2007·Journal of Virology·James HarkerJohn S Tregoning
Sep 8, 2016·Expert Review of Vaccines·Verónica A Márquez-EscobarOmar González-Ortega
Jun 1, 1987·Journal of Virology·L A Ball
Apr 1, 1990·Clinical Microbiology Reviews·D E Hruby
Apr 1, 1991·Journal of Virology·B BankampU G Liebert

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