Human rhinovirus 3 at 3.0 A resolution

Structure
R ZhaoM G Rossmann

Abstract

The over 100 serotypes of human rhinoviruses (HRV) are major causative agents of the common cold in humans. These HRVs can be roughly divided into a major and minor group according to their cellular receptors. They can also be divided into two antiviral groups, A and B, based on their sensitivity to different capsid-binding antiviral compounds. The crystal structures of HRV14 and HRV16, major-receptor group rhinoviruses, as well as HRV1A, a minor-receptor group rhinovirus, were determined previously. Sequence comparisons had shown that HRV14 seemed to be an outlier among rhinoviruses. Furthermore, HRV14 was the only virus with no cellular 'pocket factor' in a hydrophobic pocket which is targeted by many capsid-binding antiviral compounds and is thought to regulate viral stability. HRV3, another major-receptor group virus, was chosen for study because it is one of a subset of serotypes that best represents the drug sensitivity of most rhinovirus serotypes. Both HRV3 and HRV14 belong to antiviral group A, while HRV16 and HRV1A belong to antiviral group B. HRV3 was found to be very similar to HRV14 in sequence and structure. Like HRV14, crystallized HRV3 also has no bound pocket factor. The structure of HRV3 complexed with an anti...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Mar 3, 1988·Nature·K L BurkeJ W Almond
Mar 10, 1989·Cell·J M GreveA McClelland
Nov 5, 1989·Journal of Molecular Biology·S S KimM A McKinlay
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M G MurrayE Wimmer
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J BadgerM G Rossmann
Jun 1, 1988·Virology·M G Rossmann, A C Palmenberg
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R J ColonnoM A Murcko
Sep 27, 1985·Science·J M HogleD J Filman
Jul 1, 1986·Antimicrobial Agents and Chemotherapy·M P FoxM A McKinlay
May 1, 1971·Virology·K C MedappaR R Rueckert
Jan 1, 1972·Journal of Virology·K Lonberg-Holm, B D Korant
Apr 28, 1968·Journal of Molecular Biology·B W Matthews
Aug 1, 1984·Journal of Virology·G Abraham, R J Colonno
Oct 1, 1995·The Journal of General Virology·C HorsnellG Stanway
Mar 1, 1995·Nature Structural Biology·M SmythD Stuart
Oct 1, 1994·Protein Science : a Publication of the Protein Society·M G Rossmann
Sep 15, 1993·Structure·M A OliveiraM A McKinlay
Jul 1, 1994·Virology·J K Bibler-MuckelbauerM A McKinlay
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N H OlsonM G Rossmann
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·F HoferD Blaas

❮ Previous
Next ❯

Citations

Dec 22, 1999·Journal of Structural Biology·J Bella, M G Rossmann
May 17, 2000·Pharmaceutica acta Helvetiae·J Bella, M G Rossmann
Nov 5, 1997·Current Opinion in Structural Biology·K Moffat, Z Ren
Jun 19, 1998·Current Opinion in Structural Biology·J J Rux, R M Burnett
Jun 6, 2000·Trends in Microbiology·J M Casasnovas
Mar 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Pavel PlevkaMichael G Rossmann
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·A T HadfieldM G Rossmann
Mar 16, 2000·The EMBO Journal·L XingJ M Casasnovas
Apr 21, 2010·Acta Crystallographica. Section A, Foundations of Crystallography·A Janner
Feb 18, 2011·Acta Crystallographica. Section A, Foundations of Crystallography·A Janner
May 23, 2013·Acta Crystallographica. Section D, Biological Crystallography·Gaëlle SquiresFelix A Rey
May 1, 2009·Journal of Virology·Umesh KatpallyThomas J Smith
Feb 8, 2008·Journal of Virology·Matthew P DavisTobias J Tuthill
Apr 20, 2012·Journal of Virology·Jani J T SeitsonenSarah J Butcher
Apr 15, 2003·Journal of Virology·Elizabeth E FryDavid I Stuart
Aug 28, 2004·Journal of Virology·Chuan XiaoMichael G Rossmann
Jul 5, 2005·Journal of Virology·Xiaodong YanTimothy S Baker
May 24, 2008·Journal of Lipid Research·Sarah T PruettAlfred H Merrill
Nov 16, 2001·Animal Health Research Reviews·E Escribano-RomeroV Ley
Apr 21, 2009·Medical Hypotheses·Gnanadurai John FletcherManu Gnanamony
Jun 19, 2009·Cell Calcium·Yubin ZhouJenny J Yang
Apr 3, 2008·Medicinal Research Reviews·Armando M De PalmaJohan Neyts
Jun 30, 2014·Bioorganic & Medicinal Chemistry·Angela M BernardRaffaello Pompei
Jul 27, 2002·Annual Review of Microbiology·James M Hogle
Aug 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Yue LiuMichael G Rossmann
Jan 8, 1999·Journal of Molecular Biology·B G Turner, M F Summers
Feb 3, 2011·Therapeutic Advances in Respiratory Disease·Takahiko SasakiMutsuo Yamaya
Jul 12, 2005·Antiviral Chemistry & Chemotherapy·Eddy Littler, Bo Oberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.