PMID: 9421526Feb 28, 1998Paper

Human RPA (hSSB) interacts with EBNA1, the latent origin binding protein of Epstein-Barr virus

Nucleic Acids Research
D ZhangM O'Donnell

Abstract

RPA is the replicative single-strand DNA (ssDNA) binding protein of eukaryotic chromosomes. This report shows that human RPA interacts with EBNA1, the latent origin binding protein of Epstein-Barr virus (EBV). RPA binds to EBNA1 both in solution, and when EBNA1 is bound to the EBV origin. RPA is a heterotrimer, and the main contact with EBNA1 is formed through the 70 kDa subunit of RPA, the subunit which binds to ssDNA. We propose that this interaction between RPA and EBNA1 is an early step in activation of the latent origin of EBV.

References

Mar 1, 1992·Journal of Virology·L Frappier, M O'Donnell
Apr 1, 1992·Bio/technology·R Granzow, R Reed
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·L Frappier, M O'Donnell
Mar 1, 1991·Journal of Virology·R F AmbinderS D Hayward
Jul 1, 1989·Journal of Virology·T ChittendenA J Levine
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S H LeeJ Hurwitz
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M S Wold, T Kelly
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·E StiggerS H Lee
Sep 1, 1996·Genes & Development·D PhilipovaS J Brill

❮ Previous
Next ❯

Citations

Dec 28, 1999·Journal of Molecular Recognition : JMR·D G Myszka
Mar 14, 2000·Reviews in Medical Virology·E R Leight, B Sugden
Jan 1, 2009·The Journal of Biological Chemistry·Aaron C MasonMarc S Wold
May 17, 2000·The Journal of Experimental Medicine·C MünzR M Steinman
Apr 25, 2000·Journal of Virology·J L YatesJ M Bashaw
Aug 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sibille HummeAloys Schepers
Jan 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Myung-Soo KangElliott Kieff
May 25, 2010·Biochemical and Biophysical Research Communications·George KleinElena Kashuba
Apr 26, 2013·Molecular Plant Pathology·Vincent N Fondong
May 7, 2016·Acta Biochimica Et Biophysica Sinica·Ting Liu, Jun Huang
Aug 11, 2011·PLoS Pathogens·Italo TemperaPaul M Lieberman
Jan 20, 2011·PloS One·Pragya YadavLinda Spatz
Mar 8, 2005·Drug Metabolism Reviews·Shufeng ZhouYu-Zong Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.