Human schistosomiasis mansoni: intensity of infection differentially affects the production of interleukin-10, interferon-gamma and interleukin-13 by soluble egg antigen or adult worm antigen stimulated cultures

Transactions of the Royal Society of Tropical Medicine and Hygiene
Alda M S SilveiraRodrigo Corrêa-Oliveira

Abstract

The effect of the intensity of infection (eggs per gram faeces, epg) on the production of interferon-gamma (INF-gamma), interleukin (IL)-10 and IL-13 by peripheral blood mononuclear cells (PBMCs) from individuals living in a Schistosoma mansoni-endemic area was evaluated. In vitro stimulation of PBMCs with soluble egg antigen (SEA) resulted in significantly higher secretion levels of IFN-gamma in egg-negative individuals compared with those with an intensity of infection of more than 100 epg. In contrast, the egg-positive group produced significantly higher amounts of IL-10. Levels of IL-13 did not differ significantly between egg-positive and egg-negative groups. These findings suggest that IL-10 is an important cytokine in the control of the T helper cell (Th) type 1 responses during human S. mansoni infection, shifting the immune response from Th0 in egg-negative individuals from an endemic area to a Th2 polarization in chronic infected individuals.

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Citations

Jan 24, 2006·Infection and Immunity·L F Alves OliveiraR Correa-Oliveira
Jul 29, 2010·Parasites & Vectors·Barrie AnthonyDonald P McManus
Feb 3, 2007·Parasite Immunology·J JittimaneeS Wongratanacheewin
Feb 20, 2007·Memórias do Instituto Oswaldo Cruz·R Alan Wilson, Patricia S Coulson
Oct 25, 2008·Memórias do Instituto Oswaldo Cruz·Clarice Neuenschwander Lins de MoraisSilvia Maria Lucena Montenegro
Apr 26, 2018·The American Journal of Tropical Medicine and Hygiene·Bartholomew N OndigoDaniel G Colley
Mar 29, 2014·Parasite Immunology·S A RedpathG Perona-Wright
Apr 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon MetenouThomas B Nutman
Aug 28, 2020·PLoS Neglected Tropical Diseases·Vitor Hugo Simões MirandaAdriana Bozzi
Jun 28, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Tue Gia Nguyen
Jan 24, 2013·Asian Pacific Journal of Tropical Medicine·Nagla Mustafa EltayebAhmed Babiker Mohamed
Oct 6, 2009·Revista Da Sociedade Brasileira De Medicina Tropical·Maria Imaculada Muniz-JunqueiraAluízio Prata
Jan 8, 2021·International Reviews of Immunology·Tue Gia Nguyen
Jun 14, 2008·Acta Tropica·Denise Silveira-LemosRodrigo Corrêa-Oliveira

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