Human Semen Quality, Sperm DNA Damage, and the Level of Urinary Concentrations of 1N and TCPY, the Biomarkers of Nonpersistent Insecticides

American Journal of Men's Health
Emila DziewirskaJoanna Jurewicz

Abstract

The aim of the study was to evaluate the association between environmental exposure to nonpersistent insecticides and semen quality (concentration, motility, morphology, computer-aided semen analysis [CASA] parameters, and sperm DNA damage). Urine samples ( n = 315) collected from men who attended the infertility clinic with normal semen concentration of 15 to 300 mln/ml and age under 45 years were analyzed for two metabolites (1-naphthol [1N] and 3,5,6-trichloro-2-pyridinol [TCPY]) of nonpersistent insecticides. Participants provided semen, blood, and saliva samples; additionally, men filled a detailed questionnaire. The results identified that urinary TCPY concentration was significantly associated with a decrease in motility; also there was a positive association between TCPY and DNA fragmentation index (DFI). 1N concentration was negatively associated with a percentage of sperm with normal morphology and positively with one of the CASA parameters (curvilinear velocity [VCL]). The results suggest that environmental exposure to nonpersistent insecticides may have an impact on semen quality parameters and sperm DNA damage.

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Citations

Jan 12, 2021·Journal of Applied Toxicology : JAT·Quaiser SaquibAbdulaziz A Al-Khedhairy
Jul 3, 2021·International Journal of Environmental Research and Public Health·Aleksandra FucicJohn E Vena
Aug 13, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ángel Ramos-FloresBetzabet Quintanilla-Vega

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

R
R Core Team
R Foundation for Statistical Computing

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