Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering

Circulation
Elena AikawaF J Schoen

Abstract

The evolution of cell phenotypes and matrix architecture in cardiac valves during fetal maturation and postnatal adaptation through senescence remains unexplored. We hypothesized that valvular interstitial (VIC) and endothelial cell (VEC) phenotypes, critical for maintaining valve function, change throughout life in response to environmental stimuli. We performed quantitative histological assessment of 91 human semilunar valves obtained from fetuses at 14 to 19 and 20 to 39 weeks' gestation; neonates minutes to 30 days old; children aged 2 to 16 years; and adults. A trilaminar architecture appeared by 36 weeks of gestation but remained rudimentary compared with that of adult valves. VECs expressed an activated phenotype throughout fetal development. VIC density, proliferation, and apoptosis were significantly higher in fetal than adult valves. Pulmonary and aortic fetal VICs showed an activated myofibroblast-like phenotype (alpha-actin expression), abundant embryonic myosin, and matrix metalloproteinase-collagenases, which indicates an immature/activated phenotype engaged in matrix remodeling versus a quiescent fibroblast-like phenotype in adults. At birth, the abrupt change from fetal to neonatal circulation was associated wit...Continue Reading

References

Feb 1, 1991·Matrix : Collagen and Related Research·P Whittaker, P B Canham
Dec 1, 1988·The American Journal of Forensic Medicine and Pathology·J HissM Wolman
Jan 1, 1980·Anatomy and Embryology·J M HurleA M Blanco
Jul 1, 1995·Circulation Research·L M Eisenberg, R R Markwald
Nov 1, 1995·Journal of Microscopy·R Oldenbourg, G Mei
Feb 6, 1998·The Journal of Thoracic and Cardiovascular Surgery·R N MitchellF J Schoen
Mar 21, 1998·The American Journal of Surgical Pathology·W SchürchG Gabbiani
Jul 22, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R E PoelmannA C Gittenberger-de Groot
Jun 22, 2000·Heart·P JohnsonL D Allan
Oct 16, 2001·Annals of Biomedical Engineering·M W Weston, A P Yoganathan
Dec 3, 2002·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Elena Rabkin, Frederick J Schoen
Jun 27, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Joyce A SchroederTodd D Camenisch
May 1, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Jonathan T ButcherRobert M Nerem
May 27, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Joy LincolnKatherine E Yutzey
Oct 1, 2004·The Journal of Thoracic and Cardiovascular Surgery·Elena Rabkin-AikawaFrederick J Schoen

❮ Previous
Next ❯

Citations

Oct 21, 2006·Annals of Biomedical Engineering·Karen Mendelson, Frederick J Schoen
Oct 13, 2006·Annals of Biomedical Engineering·Kartik BalachandranAjit P Yoganathan
Jul 14, 2011·Journal of Cardiovascular Translational Research·M K Sewell-LoftinW David Merryman
Jul 27, 2011·Journal of Cardiovascular Translational Research·Joyce Bischoff, Elena Aikawa
Dec 8, 2010·Journal of Proteome Research·Peggi M AngelRichard M Caprioli
Nov 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kartik BalachandranKevin Kit Parker
May 24, 2007·Tissue Engineering·Antonios G MikosGordana Vunjak-Novakovic
Oct 14, 2008·Tissue Engineering. Part a·Mirjam P RubbensCarlijn V C Bouten
Jul 1, 2009·Tissue Engineering. Part a·Andrew J E AppletonKem A Rogers
Oct 10, 2009·Tissue Engineering. Part a·Elizabeth H StephensK Jane Grande-Allen
Aug 25, 2009·Tissue Engineering. Part a·Virna L SalesJohn E Mayer
Apr 24, 2012·Tissue Engineering. Part a·Stefan WeinandyStefan Jockenhoevel
May 20, 2009·Tissue Engineering. Part B, Reviews·Jesper HjortnaesJolanda Kluin
Jun 30, 2009·European Heart Journal·Katja Schenke-LaylandWilliam R MacLellan
Jun 16, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Adrian H Chester, Patricia M Taylor
Dec 18, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Jill Wylie-SearsJoyce Bischoff
Oct 30, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Gretchen J MahlerJonathan T Butcher
Jan 4, 2007·The Journal of Clinical Investigation·Filip K SwirskiMikael J Pittet
May 3, 2013·Development·Miriam VottelerKatja Schenke-Layland
Jun 12, 2010·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Elizabeth H StephensK Jane Grande-Allen
May 1, 2008·Future Cardiology·W David Merryman
Jan 22, 2014·Nature Reviews. Cardiology·Joshua D HutchesonW David Merryman
Jan 24, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Mauro Lo RitoDavid J Barron
Sep 3, 2010·Annual Review of Physiology·Robert B Hinton, Katherine E Yutzey
Jul 28, 2011·International Journal of Inflammation·Gretchen J Mahler, Jonathan T Butcher
Sep 29, 2011·Annual Review of Pathology·Frederick J Schoen
Apr 7, 2007·Current Opinion in Cardiology·Robert A Levine, Susan A Slaugenhaupt
Nov 20, 2012·Cellular and Molecular Life Sciences : CMLS·Victoria C GarsidePamela A Hoodless
Mar 26, 2013·Current Cardiology Reports·W David Merryman, Frederick J Schoen
Feb 16, 2016·Journal of Cardiovascular Development and Disease·Vinal MenonJay D Potts

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis