Human senescence

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
T B Kirkwood

Abstract

Human life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require integration of molecular, cellular, genetic and physiological approaches. This article reviews progress that has been made to date, particularly with regard to the genetic contribution to senescence and longevity, and assesses the scale of the task that remains.

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Citations

Feb 27, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R G Faragher, D Kipling
Feb 27, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D P Shanley, T B Kirkwood
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