Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis.

Biological Chemistry
Sotiria PaliouraDieter Söll

Abstract

Selenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of selenocysteine formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS) that converts phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec). The human SepSecS protein is also known as soluble liver antigen/liver pancreas (SLA/LP), which represents one of the antigens of autoimmune hepatitis. Here we review the discovery of human SepSecS and the current understanding of the immunogenicity of SLA/LP in autoimmune hepatitis.

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C GelpiJ L Rodriguez-Sanchez
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·F MeyerK Heckmann
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F ZinoniA Böck
Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P H Mäenpää, M R Bernfield
Apr 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K L TeohS P Fussey
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·M R BöslM M Taketo
Aug 30, 2000·Lancet·M P Rayman
Mar 27, 2001·EMBO Reports·R M TujebajevaM J Berry
Aug 2, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KernebeckJ Grötzinger
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Johannes HerkelAnsgar W Lohse
Jan 16, 2004·Gastroenterology·Sylvaine F A BruggraberM Eric Gershwin
Aug 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bradley A CarlsonDolph L Hatfield
Mar 26, 2005·Science·Anselm SauerwaldDieter Söll
Oct 19, 2005·Cellular and Molecular Life Sciences : CMLS·S GromerJ Jacob
Jan 6, 2006·The New England Journal of Medicine·Edward L Krawitt
Mar 8, 2006·World Journal of Gastroenterology : WJG·Chun-Xia WangJohannes Herkel
Dec 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jing YuanDieter Söll
Dec 19, 2006·Nature Chemical Biology·Alexandre AmbrogellyDieter Söll
Dec 30, 2006·PLoS Biology·Xue-Ming XuDolph L Hatfield
Dec 21, 2007·The Journal of Biological Chemistry·Oleg M GanichkinMarkus C Wahl
Dec 26, 2007·Nucleic Acids Research·Yuhei AraisoOsamu Nureki
Sep 2, 2008·The Journal of Biological Chemistry·Jun Lu, Arne Holmgren
Nov 13, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hannah R WaldenJeremy M Palmer
Mar 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eric AebyAndré Schneider
Jul 25, 2009·The Biochemical Journal·Frederick P BellingerMarla J Berry
Aug 14, 2009·Seminars in Liver Disease·Dimitrios P BogdanosDiego Vergani
Aug 21, 2009·Nucleic Acids Research·Yuzuru ItohShigeyuki Yokoyama
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yuhei AraisoOsamu Nureki
Oct 17, 2009·Science·T Martin SchmeingV Ramakrishnan
Feb 25, 2010·World Journal of Gastroenterology : WJG·Sandra BraunReinhild Klein

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Citations

Jan 1, 2013·Croatian Medical Journal·Rachel L Schmidt, Miljan Simonović
Jan 7, 2014·Brain and Behavior·Arjun V RamanMarla J Berry
Jun 2, 2015·Frontiers in Immunology·Eduardo Luiz Rachid CancadoDebora Raquel B Terrabuio
Nov 29, 2011·Best Practice & Research. Clinical Gastroenterology·Ansgar W Lohse, Christiane Wiegard
Mar 10, 2016·Arquivos De Gastroenterologia·Paulo Lisboa BittencourtPatrícia Oliveira
Jul 14, 2010·Biological Chemistry·Dirk W HeinzMatthias Wilmanns
Mar 17, 2019·Journal of Inorganic Biochemistry·Jaime M MurphyJulia L Brumaghim

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