Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity

BMC Genomics
Sibylle M GomesWalther Parson

Abstract

Distinct, partly competing, "waves" have been proposed to explain human migration in(to) today's Island Southeast Asia and Australia based on genetic (and other) evidence. The paucity of high quality and high resolution data has impeded insights so far. In this study, one of the first in a forensic environment, we used the Ion Torrent Personal Genome Machine (PGM) for generating complete mitogenome sequences via stand-alone massively parallel sequencing and describe a standard data validation practice. In this first representative investigation on the mitochondrial DNA (mtDNA) variation of East Timor (Timor-Leste) population including >300 individuals, we put special emphasis on the reconstruction of the initial settlement, in particular on the previously poorly resolved haplogroup P1, an indigenous lineage of the Southwest Pacific region. Our results suggest a colonization of southern Sahul (Australia) >37 kya, limited subsequent exchange, and a parallel incubation of initial settlers in northern Sahul (New Guinea) followed by westward migrations <28 kya. The temporal proximity and possible coincidence of these latter dispersals, which encompassed autochthonous haplogroups, with the postulated "later" events of (South) East As...Continue Reading

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Citations

Dec 3, 2016·Journal of Human Genetics·Nano NagleUNKNOWN Genographic Consortium
Dec 8, 2017·Journal of Human Genetics·Miroslava DerenkoBoris Bazarov
Feb 20, 2019·PloS One·Vincent MacaulayMartin B Richards
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Sep 29, 2017·Molecular Biology and Evolution·Georgi HudjashovMurray P Cox
Aug 3, 2019·Molecular Genetics and Genomics : MGG·Miroslava DerenkoLevon Yepiskoposyan
Jul 1, 2021·Pharmacogenomics and Personalized Medicine·Edhyana SahiratmadjaIda Parwati
Nov 11, 2021·Molecular Genetics and Genomics : MGG·Miroslava DerenkoBoris Bazarov

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Methods Mentioned

BETA
MDS

Software Mentioned

EMMA
EMPOP
Phylotree
STS
Bayesian Skyline Plot ( BSP
ARLEQUIN
Tracer
PAML
ISEA
R

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