PMID: 9662837Jul 15, 1998Paper

Human sex determination

The Journal of Experimental Zoology
A H Sinclair

Abstract

Human sex determination is a fascinating topic, particularly at the level of molecular genetics, as it represents an excellent paradigm for mammalian organ development. Recent progress has seen the addition of several new pieces to this developmental jigsaw puzzle. In mammals, the Y chromosome is male determining, and encodes a gene referred to as TDF (testis-determining factor), which induces the indifferent embryonic gonad to develop as a testis. Subsequent male sexual differentiation is largely a consequence of hormonal secretion from the testis. In the absence of the Y chromosome, the testis-determining pathway fails to be initiated, and the embryonic gonad develops as an ovary, resulting in female development. (Ford et al. [1959] Lancet i:711; Jacobs and Strong [1959] Nature, 183:302-303; Jost et al. [1973] Rec. Prog. Horm. Res., 29:1-41).

References

Feb 1, 1992·Human Genetics·J R HawkinsP N Goodfellow
Aug 1, 1991·Genes & Development·J PelletierD Housman
May 9, 1991·Nature·P KoopmanR Lovell-Badge
Jun 1, 1995·Journal of Medical Genetics·S MansourI D Young
May 1, 1995·Trends in Genetics : TIG·B Capel
Dec 1, 1993·Human Molecular Genetics·C ClépetP N Goodfellow
Jan 1, 1993·Annual Review of Genetics·P N Goodfellow, R Lovell-Badge
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·J W Foster, J A Graves
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·D R CohenJ D McGovern
Jun 1, 1993·Journal of Medical Genetics·C P BennettD Grant
Aug 27, 1993·Cell·J A KreidbergR Jaenisch
Jun 1, 1996·Current Opinion in Genetics & Development·Y Ramkissoon, P Goodfellow
Jan 1, 1997·Human Mutation·F J Cameron, A H Sinclair

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Citations

Mar 15, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·R PerneczkyA Kurz
Apr 20, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Makoto MatsuyamaKen-ichirou Morohashi
Sep 6, 2008·American Journal of Physical Anthropology·Joshua J Peck, Sam D Stout
Dec 4, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·H M GoldmanJ G Clement
Dec 13, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Liang-Hao GuoUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Eric PailhouxCorinne Cotinot
Sep 23, 2000·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·D E McFaddenG P Jevon
Mar 30, 2001·Human Reproduction·N AbusheikhaP Brinsden
Feb 23, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ozbek Mustafa, Erdogan Mehmet

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