PMID: 6976998Feb 1, 1982Paper

Human skin cells synthesize HLA-DR molecules of the same charge and molecular weight as those synthesized by autologous lymphocytes

The Journal of Investigative Dermatology
V B MorhennE G Engleman

Abstract

Between 5 and 14% of human skin cells, separated by trypsinization, express HLA-DR antigen as detected by indirect immunofluorescence with monoclonal anti-DR antibody. To determine the source and structure of these DR molecules, skin cell suspensions were biosynthetically labeled with 35S-methionine and the radiolabeled DR molecules were analyzed by the method of two-dimensional polyacrylamide gel electrophoresis. The results indicated the presence of heavy, intermediate, and light chains indistinguishable from those of B lymphocyte DR. Gels in which DR immunoprecipitates from skin cells and autologous lymphocytes were run simultaneously confirmed this finding. Thus, skin cells and lymphocytes synthesize HLA-DR antigen of identical charge and molecular weight.

References

Sep 1, 1978·British Medical Bulletin·C J BarnstableM J Crumpton
Jul 21, 1977·Nature·G RowdenA K Sullivan
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D J Charron, H O McDevitt
Mar 1, 1979·The Journal of Experimental Medicine·B S WilsonS Ferrone
Aug 1, 1978·The Journal of Investigative Dermatology·S C Liu, M Karasek
Jan 1, 1974·Tissue Antigens·H HirschbergE Thorsby
Jul 1, 1980·The Journal of Investigative Dermatology·J A Frelinger, J G Frelinger
Oct 1, 1980·The Journal of Investigative Dermatology·P M DavisonM A Karasek

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Citations

Jan 1, 1987·Archives of Dermatological Research·W Aberer, H Leibl
Jul 1, 1985·The Journal of Investigative Dermatology·B Volc-PlatzerG Stingl

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