PMID: 4100048Jan 1, 1971Paper

Human skin collagenase. The role of serum alpha-globulins in the control of activity in vivo and in vitro

Proceedings of the National Academy of Sciences of the United States of America
A Z EisenJ J Jeffrey


An antibody against human skin collagenase obtained from tissue culture has been used to demonstrate the presence of immunoreactive collagenase in human skin extracts that have no detectable enzyme activity. Gel filtration of these skin extracts permits the separation of collagenase in its active form from the other proteins in the crude mixture. The recovery of enzymatically active collagenase appears to be due to the chromatographic separation of the enzyme from the serum antiproteases, alpha(1)-antitrypsin and alpha(2)-macroglobulin, suggesting that collagenase activity in fresh tissue extracts is masked by these known collagenase inhibitors. These findings are supported by in vitro studies untilizing human skin explants in tissue culture. The demonstration of collagenase in vivo in human skin indicates that the enzyme is present at concentrations that are of physiologic significance in collagen remodeling. Evidence is also presented that these findings are not unique to human skin.


Oct 1, 1966·Biochemistry·Y NagaiJ Gross
Dec 1, 1968·The Journal of Clinical Investigation·G S LazarusH M Fullmer
Dec 1, 1968·The Journal of Clinical Investigation·J M EvansonS M Krane
Jan 1, 1969·Biochimica Et Biophysica Acta·A Z Eisen, J J Jeffrey
Dec 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H M Fullmer, G S Lazarus
Jan 20, 1970·Biochemistry·J J Jeffrey, J Gross
Mar 25, 1968·Biochimica Et Biophysica Acta·A Z EisenJ Gross
Feb 12, 1966·Nature·H M Fullmer, W Gibson
Jun 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·J GROSS, C M LAPIERE

❮ Previous
Next ❯


Jan 1, 1972·Archiv Für Dermatologische Forschung·J E Fräki, V K Hopsu-Havu
Jan 1, 1972·Archiv Für Dermatologische Forschung·J E Fräki, V K Hopsu-Havu
Jan 1, 1972·Calcified Tissue Research·S SakamotoM J Glimcher
Sep 1, 1971·Developmental Biology·J Gross, A B Bruschi
Jan 1, 1981·The International Journal of Biochemistry·M FujiiK Koga
Jan 1, 1984·Tissue & Cell·J P Denefle, J P Lechaire
Sep 12, 1974·The New England Journal of Medicine·E D Harris, S M Krane
Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E A Bauer
May 1, 1979·International Journal of Dermatology·E A Bauer, J Uitto
Apr 1, 1978·The Australasian Journal of Dermatology·M EisenbergP J Schofield
Jan 1, 1974·Acta Pathologica Japonica·G UsukuT Ogata
Jan 1, 1974·Journal of Oral Pathology·H Birkedal-HansenH M Fullmer
Jan 1, 1974·Journal of Oral Pathology·H Birkedal-HansenH M Fullmer
Jan 1, 1976·Journal of Oral Pathology·S B Heard
Sep 1, 1975·Scandinavian Journal of Dental Research·H Birkedal-HansenH M Fullmer
Oct 1, 1971·The Journal of Clinical Investigation·E A BauerJ J Jeffrey
Jun 1, 1994·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·H J HertfelderP Hanfland
Jan 1, 1976·Journal of Periodontology·P B Robertson, J Simpson
Aug 1, 1980·Journal of Periodontology·P Christner
Aug 31, 1972·Biochimica Et Biophysica Acta·S Abe, Y Nagai
May 1, 1980·World Journal of Surgery·I K Cohen, B J McCoy
Aug 12, 1976·Biochimica Et Biophysica Acta·J G WeeksJ F Woessner
Apr 8, 1976·Biochimica Et Biophysica Acta·M Hino, T Nagatsu
Mar 11, 1976·Biochimica Et Biophysica Acta·H Birkedal-HansenH M Fullmer
Dec 29, 1974·Biochimica Et Biophysica Acta·I Sopata, A M Dancewicz
Jan 20, 1972·Biochimica Et Biophysica Acta·Y TokoroJ J Jeffrey
Jul 27, 1973·Biochimica Et Biophysica Acta·Y Nagai, H Hori
Jan 1, 1977·Connective Tissue Research·G Wirl
Jan 1, 1974·Connective Tissue Research·A Pardo, R PEREZ-Tamayo
Jan 1, 1982·Connective Tissue Research·B J McCoy, I K Cohen
Sep 1, 1975·Analytical Biochemistry·M T Gisslow, B C McBride
Sep 5, 1972·Biochemical and Biophysical Research Communications·E Harper, J Gross
Nov 1, 1972·Biochemical and Biophysical Research Communications·B S Strates, M R Urist
Feb 14, 1978·Biochemical and Biophysical Research Communications·J L SeltzerJ Feder
May 5, 1975·Biochemical and Biophysical Research Communications·E A BauerA Z Eisen
Jun 3, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Jerome Gross
Jan 1, 1976·Archives of Oral Biology·H Birkedal-HansenH M Fullmer
Oct 1, 1975·Archives of Oral Biology·H Birkedal-HansenH M Fullmer
Sep 16, 1975·Biochemical and Biophysical Research Communications·D E WoolleyJ M Evanson
Jan 1, 1983·Journal of Periodontal Research·M YanagimuraH Nohara
Jul 1, 1983·The Journal of Dermatologic Surgery and Oncology·S J Salasche, W J Grabski
Jan 1, 1992·Archives of Gerontology and Geriatrics·H Niedermüller, R D Petersen
Feb 1, 1988·Oral Surgery, Oral Medicine, and Oral Pathology·W T McGaw, H Porter

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

Clinica Chimica Acta; International Journal of Clinical Chemistry
P B RobertsonH M Fullmer
Biochemical and Biophysical Research Communications
E Harper, J Gross
Journal of Periodontal Research
P B RobertsonH M Fullmer
© 2021 Meta ULC. All rights reserved