Human Skin Explants Recapitulate Key Features of HSV-1 Infections

The Journal of Investigative Dermatology
Megan H Orzalli

Abstract

The development of novel antiviral compounds is hindered by the lack of model systems that recapitulate the pathophysiology of human infections. Tajpara et al. developed an ex vivo human abdominal skin model of HSV-1 infection to examine host-pathogen interactions and test the efficacy of antiviral compounds. This approach provides a platform for future development and testing of antiviral drugs.

References

Nov 17, 2010·Antimicrobial Agents and Chemotherapy·Jocelyne Piret, Guy Boivin
Jan 15, 2016·The Journal of Investigative Dermatology·Betty Y KongAmy S Paller
Feb 22, 2016·Current Opinion in Virology·Alexander Birkmann, Holger Zimmermann
Aug 3, 2016·Annual Review of Pharmacology and Toxicology·Maaike EvertsRichard J Whitley
May 22, 2017·Advances in Anatomy, Embryology, and Cell Biology·Evelyn A Kurt-JonesDavid M Knipe
Jun 24, 2017·Trends in Cell Biology·Megan H Orzalli, Jonathan C Kagan
Jan 1, 2018·Journal of Dermatological Science·Helena D Zomer, Andrea G Trentin
Nov 12, 2018·The Journal of Investigative Dermatology·Poojabahen TajparaAdelheid Elbe-Bürger

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