Human skin permeation of emerging mycotoxins (beauvericin and enniatins)

Journal of Exposure Science & Environmental Epidemiology
Lien TaevernierBart De Spiegeleer

Abstract

Currently, dermal exposure data of cyclic depsipeptide mycotoxins are completely absent. There is a lack of understanding about the local skin and systemic kinetics and effects, despite their widespread skin contact and intrinsic hazard. Therefore, we provide a quantitative characterisation of their dermal kinetics. The emerging mycotoxins enniatins (ENNs) and beauvericin (BEA) were used as model compounds and their transdermal kinetics were quantitatively evaluated, using intact and damaged human skin in an in vitro Franz diffusion cell set-up and ultra high-performance liquid chromatography (UHPLC)-MS analytics. We demonstrated that all investigated mycotoxins are able to penetrate through the skin. ENN B showed the highest permeation (kp,v=9.44 × 10(-6) cm/h), whereas BEA showed the lowest (kp,v=2.35 × 10(-6) cm/h) and the other ENNs ranging in between. Combining these values with experimentally determined solubility data, Jmax values ranging from 0.02 to 0.35 μg/(cm(2) h) for intact skin and from 0.07 to 1.11 μg/(cm(2) h) for damaged skin were obtained. These were used to determine the daily dermal exposure (DDE) in a worst-case scenario. On the other hand, DDE's for a typical occupational scenario were calculated based on ...Continue Reading

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Citations

Mar 11, 2016·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Lien TaevernierBart De Spiegeleer
Sep 1, 2015·Journal of Pharmaceutical and Biomedical Analysis·Lieselotte VeryserBart De Spiegeleer
Aug 14, 2018·Annals of Work Exposures and Health·Susana ViegasAnne Oppliger
Sep 29, 2018·Mini Reviews in Medicinal Chemistry·Qinghua WuKamil Kuca
Mar 4, 2020·Antimicrobial Agents and Chemotherapy·Charbel Al KhouryJacques Guillot
Dec 6, 2018·Frontiers in Pharmacology·Qinghua WuKamil Kuca
Jan 21, 2021·Toxins·Ludmila KřížováTomáš Kašparovský

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