PMID: 11934532Apr 6, 2002Paper

Human sperm immobilizing activity of aminophenyl arsenic acid and its N-substituted quinazoline, pyrimidine, and purine derivatives: protective effect of glutathione

Reproductive Toxicology
Fatih M UckunOsmond J D'Cruz

Abstract

We examined the potential toxicity of pentavalent organic arsenicals for human sperm. We used computer-assisted sperm analysis to examine the effects of three aminophenyl arsenicals and their nine N-substituted quinazoline, pyrimidine, and purine derivatives on human sperm motility and kinematics in human semen and medium. Among the arsenicals examined, (aminophenylazo)-phenyl arsonic acid and its N-substituted pyrimidine derivative PHI-370 (2-methylthio-4-[(4'-aminophenylazo)-phenylarsonic acid] pyrimidine) exhibited rapid sperm immobilizing activity in medium with EC(50) values of 77 and 82 microM, respectively, and t(1/2) of < 3 min. Molecular modeling analysis indicated that sperm-immobilizing organic arsenicals exhibit high dipole moments (>7 Debyes). Sperm immobilizing activity of these arsenicals was completely abrogated in the presence of seminal plasma. Furthermore, coincubation of motile sperm with PHI-370 in the presence of reduced glutathione (GSH) resulted in dose-dependent protection of sperm motility and sperm motion parameters. Coincubation of the arsenical with GSH at a molar ratio of 1:20 resulted in 95% retention of sperm progressive motility. The mean values of the other sperm movement characteristics also s...Continue Reading

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Citations

Aug 31, 2006·International Journal of Toxicology·Amy WangJohn L Robertson
Jul 11, 2012·Environmental Health : a Global Access Science Source·Weipan XuHeqing Shen
Oct 15, 2010·The Journal of Veterinary Medical Science·Ming ZhangLixin Wen
Nov 30, 2010·Ecotoxicology and Environmental Safety·M Reshma AnjumP Sreenivasula Reddy
Jan 8, 2009·Reproductive Toxicology·Cesare CastelliniTommaso Renieri
Jun 10, 2014·Andrologia·M Reshma Anjum, P Sreenivasula Reddy
Jun 7, 2016·Environmental Science and Pollution Research International·Pushpa Rani GuvvalaRavindra Janivara Parameswaraiah
Mar 15, 2016·Balsaeng'gwa saengsig·Yoon-Jae Kim, Jong-Min Kim
Feb 23, 2021·Andrologia·Temitayo Olabisi Ajibade, Funsho Olakitike Olayemi
Sep 30, 2018·Life Sciences·Kaviyarasi RenuAbilash Valsala Gopalakrishnan
May 26, 2021·The Science of the Total Environment·Jochen BundschuhAbhijit Mukherjee

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