Human stem cell decorated nanocellulose threads for biomedical applications

Biomaterials
Henrikki MertaniemiMarjo Yliperttula

Abstract

Upon surgery, local inflammatory reactions and postoperative infections cause complications, morbidity, and mortality. Delivery of human adipose mesenchymal stem cells (hASC) into the wounds is an efficient and safe means to reduce inflammation and promote wound healing. However, administration of stem cells by injection often results in low cell retention, and the cells deposit in other organs, reducing the efficiency of the therapy. Thus, it is essential to improve cell delivery to the target area using carriers to which the cells have a high affinity. Moreover, the application of hASC in surgery has typically relied on animal-origin components, which may induce immune reactions or even transmit infections due to pathogens. To solve these issues, we first show that native cellulose nanofibers (nanofibrillated cellulose, NFC) extracted from plants allow preparation of glutaraldehyde cross-linked threads (NFC-X) with high mechanical strength even under the wet cell culture or surgery conditions, characteristically challenging for cellulosic materials. Secondly, using a xenogeneic free protocol for isolation and maintenance of hASC, we demonstrate that cells adhere, migrate and proliferate on the NFC-X, even without surface modi...Continue Reading

References

Sep 1, 1990·Journal of Biomedical Materials Research·L L Huang-LeeM E Nimni
Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Aug 16, 2005·Biomaterials·Wojciech CzajaR Malcolm Brown
Jun 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sharon GerechtGordana Vunjak-Novakovic
May 24, 2008·Biomacromolecules·Marielle HenrikssonTakashi Nishino
Aug 21, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xabier L ArangurenAernout Luttun
Oct 9, 2009·Journal of the Royal Society, Interface·S J Eichhorn, W W Sampson
Dec 23, 2009·Nature Reviews. Molecular Cell Biology·Harvey W Smith, Chris J Marshall
Nov 19, 2010·Alimentary Pharmacology & Therapeutics·P J TozerA L Hart
Feb 10, 2011·Biomacromolecules·Shinichiro IwamotoTadahisa Iwata
Feb 16, 2011·Macromolecular Bioscience·Jennifer M Singelyn, Karen L Christman
May 21, 2011·Angewandte Chemie·Dieter KlemmAnnie Dorris
Jun 29, 2011·Stem Cell Reviews and Reports·Carmen Escobedo-LuceaMiodrag Stojkovic
Jul 12, 2011·Applied Microbiology and Biotechnology·Nathan Petersen, Paul Gatenholm
Oct 15, 2011·Tissue Engineering. Part B, Reviews·Joyce DoornJan de Boer
May 2, 2012·Endocrine Reviews·Maria DalamagaChristos S Mantzoros
May 9, 2012·Plastic Surgery International·Patrick S Murphy, Gregory R D Evans
Jun 6, 2012·TheScientificWorldJournal·T F FuchsG Schmidmaier
Jun 13, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tihomir Georgiev-HristovDamián García-Olmo
Jul 11, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Madhushree BhattacharyaMarjo Yliperttula
Aug 11, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Yan LiGregory N Tew
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Sep 11, 2012·Journal of Biomedical Materials Research. Part a·Jacques P GuyetteGlenn R Gaudette
Nov 30, 2012·Biotechnology Journal·Brandon G Gerberich, Sujata K Bhatia
Mar 19, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hanna ValoTimo Laaksonen
May 15, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jessica F AlmineAnthony S Weiss
Jul 23, 2013·PloS One·Carmen Escobedo-LuceaJosé M Garcia-Verdugo
Jan 31, 2014·International Journal of Molecular Sciences·Hyun Hee AhnMoon Suk Kim
Mar 15, 2014·PloS One·Ann Katharin ReckhenrichJosé Tomás Egaña
May 23, 2014·Nature Materials·Matthew J DalbyRichard O C Oreffo
May 23, 2014·Nature Materials·Adam D CelizMorgan R Alexander
Jun 3, 2014·Nature Communications·Karl M O HåkanssonL Daniel Söderberg

❮ Previous
Next ❯

Citations

Nov 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·David MoreauLaurent Corté
Mar 6, 2018·Advanced Materials·Eero KontturiOlli Ikkala
Aug 29, 2018·Small·Kaitao Zhang, Henrikki Liimatainen
Oct 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali H TayebMehdi Tajvidi
Dec 12, 2019·Critical Reviews in Food Science and Nutrition·Dinh-Chuong PhamBharath Kumar Velmurugan
Feb 19, 2020·Macromolecular Bioscience·Yeyi ChenChangcan Shi
Aug 25, 2020·Advanced Materials·Tomas RosénL Daniel Söderberg
Sep 15, 2020·Frontiers in Bioengineering and Biotechnology·Dawei LiJin Zhou
May 28, 2019·Journal of Biomaterials Science. Polymer Edition·Jie WangLei Liu
Nov 11, 2019·Waste Management·Varun KumarNishi Kant Bhardwaj
Nov 28, 2020·Colloids and Surfaces. B, Biointerfaces·M R PoornaUllas Mony
Mar 27, 2021·Carbohydrate Polymers·Kara M de la HarpeYahya E Choonara
Apr 20, 2021·Advanced Materials·Mei-Chun LiMichael J Bortner
May 28, 2019·International Journal of Biological Macromolecules·Jegan AthinarayananAli A Alshatwi
Apr 1, 2018·Nature Reviews. Materials·Shengjie LingMarkus J Buehler
Aug 7, 2021·Bioengineering·Jennifer RosendahlJoakim Håkansson
Apr 3, 2020·Biomacromolecules·Andreas WaltherLennart Bergström
May 6, 2017·ACS Nano·Nitesh MittalL Daniel Söderberg
Apr 21, 2018·ACS Applied Materials & Interfaces·Tina TronserPavel A Levkin
Aug 22, 2021·Small·Ruimin XiaoXuqing Liu
Oct 5, 2021·Expert Opinion on Drug Delivery·Munira MominAbdelwahab Omri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.