PMID: 8955581Nov 1, 1996Paper

Human T and B cell immune responses to Fel d 1 in cat-allergic and non-cat-allergic subjects

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
P G MarkR D Garman

Abstract

In allergic individuals exposure to allergen leads to the induction of allergen-specific IgE which, upon binding to its high affinity receptors on mast cells and basophils, primes these cells for degranulation. This degranulation, a result of specific IgE/allergen-interaction, initiates the debilitating symptoms of allergy and the potentially life-threatening symptoms of anaphylaxis. The lack of symptoms following antigen encounter by non-allergic individuals is probably due to the undetectable levels of allergen-specific IgE in the plasma of non-allergic individuals. To compare the immune responses of allergic and non-allergic individuals. We compared the immune responses of 42 cat-allergic subjects with 16 non-cat-allergic subjects to the major cat allergen, Fel d 1. We have measured plasma immunoglobulin levels and the proliferative responses of fel d 1 primed T cell lines to Fel d 1 peptides. While these two groups have similar levels of Fel d 1 specific IgG, only subjects in the cat-allergic group have detectable Fel d 1 specific IgE. Affinity purified Fel d 1 was used to generate T cell lines from peripheral blood mononuclear cells of these same subjects. The proliferative responses of these T cell lines to intact Fel d 1...Continue Reading

Citations

Jan 23, 1999·Current Opinion in Immunology·J Rolland, R O'Hehir
Sep 24, 2005·Nature Immunology·P G Holt, W R Thomas
Sep 26, 2006·Nature Reviews. Immunology·Mark LarchéRudolf Valenta
Sep 17, 2008·Clinical and Molecular Allergy : CMA·Scott J Melton, Samuel J Landry
Feb 13, 2007·The Journal of Allergy and Clinical Immunology·Judith A Woodfolk
Mar 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B BohleC Ebner
Jun 23, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T KinnunenT Virtanen
Jan 8, 2011·The Journal of Allergy and Clinical Immunology·Margitta WormMark Larché
Mar 27, 2009·Veterinary Dermatology·Christine Loewenstein, Ralf S Mueller

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