Human T Cell Development, Localization, and Function throughout Life

Immunity
Brahma V KumarDonna L Farber

Abstract

Throughout life, T cells coordinate multiple aspects of adaptive immunity, including responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is studied in the context of a specific type of pathogen, antigen, or disease condition over a limited time frame, whereas in humans, T cells control multiple insults simultaneously throughout the body and maintain immune homeostasis over decades. In this review, we discuss how human T cells develop and provide essential immune protection at different life stages and highlight tissue localization and subset delineation as key determinants of the T cell functional role in immune responses. We also discuss how anatomic compartments undergo distinct age-associated changes in T cell subset composition and function over a lifetime. It is important to consider age and tissue influences on human T cells when developing targeted strategies to modulate T cell-mediated immunity in vaccines and immunotherapies.

Citations

Dec 12, 2018·Journal of Leukocyte Biology·Karla F Castro-OchoaMichael Schnoor
Nov 2, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael A BrehmLeonard D Shultz
May 1, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nabil ZeidanVibhuti P Dave
Jun 18, 2019·FEBS Letters·A Michael DowneyPeter H Seeberger
Sep 4, 2019·Nature Reviews. Nephrology·Yuki Sato, Motoko Yanagita
Sep 20, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Yannick D MullerUNKNOWN Swiss Transplant Cohort Study
Dec 11, 2019·Briefings in Functional Genomics·Anne van SchoonhovenRalph Stadhouders
Jan 14, 2020·PLoS Biology·Eleni StampouloglouXaralabos Varelas
Dec 6, 2019·Science Translational Medicine·Amanda S Woodward DavisMartin Prlic
Feb 29, 2020·Cells·Itay RaphaelThomas G Forsthuber
Feb 14, 2020·Current HIV/AIDS Reports·Barbara L ShacklettBrenna E Kiniry
May 21, 2020·Nature Reviews. Immunology·Alex D WaldmanMichael J Lenardo
May 7, 2020·British Journal of Clinical Pharmacology·Hui Yi ChewFiona Simpson
Jul 19, 2019·Glycobiology·Christopher E CutlerRichard D Cummings
Aug 9, 2020·International Immunology·Ozlem BulutMihai G Netea
Sep 8, 2020·Pharmacogenomics·Wlisses Henrique Veloso Carvalho-SilvaRafael Lima Guimarães
Aug 26, 2020·ELife·Jeanette Baran-GaleGeorg A Holländer
Jul 2, 2020·American Journal of Respiratory Cell and Molecular Biology·Andrew D PriggeKaren M Ridge
Aug 9, 2018·Frontiers in Immunology·Evgeny S EgorovOlga V Britanova
Aug 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Hesham M ShehataShomyseh Sanjabi
Dec 13, 2018·Frontiers in Immunology·Márcia S PereiraSalomé S Pinho
Oct 22, 2019·European Journal of Immunology·Andrea CossarizzaArturo Zychlinsky
Nov 7, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sinead E MorrisAndrew J Yates
Aug 27, 2019·Frontiers in Immunology·Elena N NaumovaJack Gorski
Oct 23, 2019·International Journal of Molecular Sciences·Hadia M AbdelaalPamela J Skinner
Sep 20, 2020·Science Immunology·Jenna L PappalardoDavid A Hafler
Aug 28, 2020·Frontiers in Immunology·Julienne KnolleMonika C Brunner-Weinzierl
Jun 16, 2018·Frontiers in Immunology·Shiki Takamura
Jan 4, 2019·Nature Cell Biology·Jonathan JungTiffany Horng
Feb 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·D BichoJ M Oliveira
Apr 8, 2020·Frontiers in Immunology·Charles Caër, Mary Jo Wick
Feb 23, 2020·Science·Jong-Eun ParkSarah A Teichmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.