PMID: 6982476Sep 1, 1982Paper

Human T-cell leukemia-lymphoma virus (HTLV) is in T but not B lymphocytes from a patient with cutaneous T-cell lymphoma

Proceedings of the National Academy of Sciences of the United States of America
R GalloM S Reitz

Abstract

A human type C retrovirus, designated HTLV, previously was isolated from or identified in some patients with leukemias and lymphomas of mature T lymphocytes. HTLV is genetically and serologically distinct from any known animal retroviruses. The absence of HTLV proviral sequences in DNA from normal humans showed that HTLV is not a ubiquitous endogenous (germ-line transmitted) virus of humans. Antibodies to HTLV core proteins have been identified in some people with T-cell neoplasias and are particularly prevalent in Japanese with adult T-cell leukemia, suggesting that HTLV is acquired horizontally. However, it was possible that HTLV is transmitted through the germ line of some (possibly rare) families and is then expressed in the HTLV- positive malignancies. An opportunity to study this question was provided by the development of several T-cell lines and a B-cell provided by the development of several T-cell lines and a B-cell line from one HTLV-positive patient with a cutaneous T-cell lymphoma. Here we report that HTLV proteins or nucleic acids (or both) are found in three independently derived T-cell lines, all shown by HLA typing to have originated from the patient. In contrast, the B-cell line, the identity of which was also...Continue Reading

References

Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·W BaxtS Spiegelman
Nov 1, 1972·The Journal of General Virology·D J Moss, J H Pope
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M S ReitzR C Gallo
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·V S KalyanaramanR C Gallo
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J W Mier, R C Gallo
Aug 1, 1981·The Journal of Experimental Medicine·L E PosnerR C Gallo
Nov 1, 1981·The Journal of Experimental Medicine·J E GootenbergR C Gallo
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M YoshidaY Hinuma
Jan 1, 1981·Immunological Reviews·B F Haynes
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y HinumaI Miyoshi

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Citations

Dec 15, 1983·Klinische Wochenschrift·R HehlmannA Luz
Jan 1, 1995·Journal of Biomedical Science·A.A. Franklin, J.K. Nyborg
Jan 1, 1985·Pharmacology & Therapeutics·P S Sarin, R C Gallo
Sep 14, 1992·Biochimica Et Biophysica Acta·J Sodroski
Jul 30, 1983·Lancet·P A BottomleyR W Redington
Aug 6, 1983·Lancet
Apr 7, 1983·The New England Journal of Medicine·D W BlayneyR C Gallo
Oct 6, 1983·The New England Journal of Medicine·P H Black, E M Levy
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M PopovicR C Gallo
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·V ManzariR C Gallo
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P S SarinR C Gallo
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E P GelmannR C Gallo
Jan 1, 1987·Viral Immunology·D ArchibaldN Mueller
May 26, 1998·Australasian Radiology·P NgP Despas
Mar 1, 1997·Journal of Clinical Pathology·S YamanoI Saito
Mar 1, 1985·The Journal of Clinical Investigation·C MorimotoS F Schlossman
Nov 1, 1986·The Journal of Clinical Investigation·H MitsuyaS Broder
Dec 1, 2007·Biomedical Engineering Online·Marios S NeofytouDimitris D Koutsouris
Jan 1, 1987·The American Journal of Medicine·P A Mackowiak
Jan 1, 1990·Critical Reviews in Oncology/hematology·J CossmanL J Medeiros
Oct 1, 1987·The Journal of Dermatology·R L Edelson
Jan 1, 1987·Annals of the New York Academy of Sciences·C Gurgo, R C Gallo
Sep 15, 1982·International Journal of Cancer. Journal International Du Cancer·W A BlattnerR C Gallo
Sep 1, 1986·British Journal of Haematology·K YasudaA Hara

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