Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 tax oncoproteins modulate cell cycle progression and apoptosis

Journal of Virology
Michelle SieburgGerold Feuer

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia and lymphoma, an aggressive clonal malignancy of human CD4-bearing T lymphocytes. HTLV-2, although highly related to HTLV-1 at the molecular level, has not been conclusively linked to development of lymphoproliferative disorders. Differences between the biological activities of the respective tax gene products (Tax1 and Tax2) may be one factor which accounts for the differential pathogenicities associated with infection. To develop an in vitro model to investigate and compare the effects of constitutive expression of Tax1 and Tax2, Jurkat T-cell lines were infected with lentivirus vectors encoding Tax1 and Tax2 in conjunction with green fluorescent protein, and stably transduced clonal cell lines were generated by serial dilution in the absence of drug selection. Jurkat cells that constitutively express Tax1 and Tax2 (Tax1/Jurkat and Tax2/Jurkat, respectively) showed notably reduced kinetics of cellular replication, and Tax1 inhibited cellular replication to a higher degree in comparison to Tax2. Tax1 markedly activated transcription from the cdk inhibitor p21(cip1/waf1) promoter in comparison to Tax2, suggesting that upregulation of p21...Continue Reading

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Citations

Apr 6, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Paul W Ewald, Holly A Swain Ewald
Apr 6, 2006·The Journal of Clinical Investigation·David SibonEric Wattel
Nov 16, 2005·Retrovirology·Sébastien A ChevalierRenaud Mahieux
Mar 23, 2006·Retrovirology·Noreen SheehyWilliam Hall
Mar 15, 2014·PLoS Pathogens·Anat MelamedCharles R M Bangham
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Giovanna TosiRoberto S Accolla
Jul 26, 2006·Pediatric Research·Saskia EklindCarina Mallard
Jun 19, 2010·Chemico-biological Interactions·Katerina Chlichlia, Khashayarsha Khazaie
Sep 7, 2005·Biochemical and Biophysical Research Communications·Hung-Jen LiuWen-Ling Shih
Sep 2, 2005·Cancer·Farhad RavandiSusan O'Brien

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