Human T cell leukemia virus type 1 infection drives spontaneous proliferation of natural killer cells.

Virulence
Philip J NorrisEdward L Murphy

Abstract

Most human T cell leukemia virus type 1 (HTLV-1) infected subjects remain asymptomatic throughout their lives, with a few individuals developing HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T cell leukemia. Lymphocytes from about half of HTLV-1 infected subjects spontaneously proliferate in vitro, and how this phenomenon relates to symptomatic disease outcome and viral burden is poorly understood. Spontaneous proliferation was measured in lymphocyte subsets, and these findings were correlated with HTLV-1 proviral load and Tax expression in PBMCs. We found that in addition to previously described vigorous CD8+ T cell spontaneous proliferation, natural killer (NK) cells spontaneously proliferated to a similar high level, resulting in expansion of CD56-expressing NK cells. Spontaneous NK cell proliferation positively correlated with HTLV-1 proviral load but not with Tax expression or the presence of HAM/TSP. The strongest correlate with clinical outcome in this cohort was the ability of cells to express Tax, while HTLV-1 proviral load was more closely related to spontaneous NK cell proliferation. These results demonstrate that spontaneous proliferation, Tax expression, and proviral load are inter-re...Continue Reading

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Citations

Oct 14, 2011·Viruses·Chloé Journo, Renaud Mahieux
Mar 29, 2011·Antiviral Research·Jenny Shvarzbeyn, Mahmoud Huleihel
Jun 21, 2016·Expert Opinion on Therapeutic Targets·Alma Chávez-BlancoAlfonso Duenas-Gonzalez
Aug 26, 2014·BMC Infectious Diseases·Raimundo CoutinhoRita Elizabeth Mascarenhas
Oct 28, 2016·Journal of Medical Virology·Sayed-Hamidreza MozhganiMehdi Norouzi
Jun 19, 2014·The Journal of Biological Chemistry·Elizabeth JaworskiFatah Kashanchi
May 19, 2019·BMC Infectious Diseases·Gabriel Andrade Nonato QueirozMaria Fernanda Rios Grassi
Apr 5, 2019·Journal of Immunology Research·Camila F AmorimEdgar M Carvalho
Nov 13, 2021·PLoS Neglected Tropical Diseases·Brenda RocamondeHélène Dutartre

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