PMID: 9546394Apr 18, 1998Paper

Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1

Cell
D Y JinK T Jeang

Abstract

In searching for cellular targets of the HTLV-I oncoprotein Tax, we identified TXBP181, which we characterized as the human homolog of yeast mitotic checkpoint MAD1 protein. Evidence supporting TXBP181 as HsMAD1 includes sequence conservation with yeast MAD1, hyperphosphorylation during S/G2/M phases and upon treatment of cells with nocodazole, and binding to HsMAD2. HsMAD1 functions as a homodimer. It localizes to the centrosome during metaphase and to the spindle midzone and the midbody during anaphase and telophase. Expression of either Tax or a transdominant-negative TXBP181 results in multinucleated cells, a phenotype consistent with a loss of HsMAD1 function. We propose a model of viral transformation in which Tax targets TXBP181, thereby abrogating a mitotic checkpoint.

References

Aug 9, 1991·Cell·R Li, A W Murray
May 24, 1991·Science·A LupasJ Stock
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A L KungR T Schimke
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A TanakaM Hatanaka
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M YoshidaY Hinuma
Dec 1, 1995·The Journal of Biological Chemistry·M N UittenbogaardJ K Nyborg
Nov 1, 1995·The Journal of Cell Biology·K G Hardwick, A W Murray
Mar 3, 1995·Science·S M CrossB J Reid
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Mar 22, 1996·Science·K FukasawaG F Vande Woude
Oct 11, 1996·Science·Y Li, R Benezra
Aug 1, 1996·Molecular Biology of the Cell·F Pangilinan, F Spencer
Dec 1, 1996·Current Opinion in Cell Biology·A D Rudner, A W Murray
Jan 31, 1997·Science·R B Nicklas
Jan 15, 1997·Nucleic Acids Research·D Y Jin, K T Jeang
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·S M PockwinseS Penman
Jan 1, 1997·Annual Review of Immunology·T Uchiyama
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·K Oegema, T J Mitchison
May 1, 1997·Cellular Signalling·A D Laird, D Shalloway
Sep 26, 1997·Nature·K PolyakB Vogelstein
Nov 5, 1997·The Journal of Biological Chemistry·D Y JinK T Jeang
Feb 7, 1998·The Journal of Biological Chemistry·M L AgarwalG R Stark
Jan 13, 1998·Current Opinion in Cell Biology·M Glotzer
Jan 1, 1995·Journal of Biomedical Science·A.A. Franklin, J.K. Nyborg

❮ Previous
Next ❯

Citations

Jul 13, 2000·Cell Motility and the Cytoskeleton·M S CampbellG J Gorbsky
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Yasushi SasakiKohzoh Imai
May 27, 1999·Journal of Biomedical Science·A Krause BoehmS H Hinrichs
Dec 23, 2003·International Journal of Hematology·Genoveffa FranchiniJake R Fullen
Mar 30, 2007·Journal of Cancer Research and Clinical Oncology·Takashi KuzuharaHirota Fujiki
Jul 30, 2011·Bulletin de la Société de pathologie exotique·J-F Pays
Jan 24, 2004·Journal of Virological Methods·Matthew D AndersonPatrick L Green
Sep 26, 2002·Virus Research·Julie M Johnson, Genoveffa Franchini
Oct 22, 2003·Archives of Medical Research·Carla S Lopes, Claudio E Sunkel
Jan 23, 1999·Current Opinion in Cell Biology·P D Adams, W G Kaelin
Apr 27, 1999·Trends in Biochemical Sciences·K Nasmyth
Sep 3, 2003·Nature Reviews. Cancer·Harith RajagopalanChristoph Lengauer
Oct 1, 2005·Nature Reviews. Cancer·Geert J P L KopsDon W Cleveland
Mar 27, 2007·Nature Reviews. Cancer·Masao Matsuoka, Kuan-Teh Jeang
Oct 3, 2002·Nature Reviews. Molecular Cell Biology·Andrea Musacchio, Kevin G Hardwick
Sep 13, 2005·Oncogene·Susan J Marriott, Oliver John Semmes
Sep 13, 2005·Oncogene·Ralph GrassmannKuan-Teh Jeang
Aug 12, 2008·The Journal of Biological Chemistry·Lova RakotomalalaOurania Andrisani
Nov 18, 2000·AIDS Research and Human Retroviruses·X H Li, R B Gaynor
Nov 18, 2000·AIDS Research and Human Retroviruses·Y L KuoC Z Giam
Nov 18, 2000·AIDS Research and Human Retroviruses·M Yoshida, T Suzuki
Feb 3, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yaël MamaneJohn Hiscott
May 15, 2002·Molecular Biology of the Cell·Eunah Chung, Rey-Huei Chen
Apr 11, 2003·Molecular Biology of the Cell·Song-Tao LiuTim J Yen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.