PMID: 9557741Apr 29, 1998Paper

Human T-cell leukemia virus type 1 pX-I and pX-II open reading frames are dispensable for the immortalization of primary lymphocytes

Journal of Virology
M D RobekLee Ratner

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) infects and transforms CD4+ T-lymphocytes both in vivo and in vitro. Although the Tax protein of HTLV-1 has been strongly implicated as a transforming agent, other virally encoded proteins may also play a role in the transformation process. In addition to the rex and tax genes, the pX region of the HTLV-1 genome contains two open reading frames (pX-I and pX-II) which encode the putative viral accessory proteins known as p12I, p30II, and p13II. Mutations in the ACH molecular clone of HTLV-1 that are predicted to abrogate the expression of p12I, p13II and p30II were constructed. These mutations had no effect on viral replication or the immortalization of primary lymphocytes. Although these proteins are dispensable for viral replication and immortalization in vitro, it remains possible that they alter infection in vivo.

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Citations

Dec 9, 2004·AIDS Research and Human Retroviruses·Tomonori Tsukahara, Lee Ratner
Sep 13, 2005·Oncogene·Christophe NicotGenoveffa Franchini
Aug 8, 2001·International Journal of Experimental Pathology·J M JohnsonG Franchini
Sep 13, 2005·Oncogene·Ralph GrassmannKuan-Teh Jeang
Sep 5, 2002·Microbiology and Molecular Biology Reviews : MMBR·Björn Albrecht, Michael D Lairmore
Dec 23, 2003·International Journal of Hematology·Genoveffa FranchiniJake R Fullen
Mar 12, 2005·Cell Death and Differentiation·D M D'AgostinoV Ciminale
Feb 24, 2011·Antimicrobial Agents and Chemotherapy·Muhammad Esa Seegulam, Lee Ratner
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seung-Jae KimMichael D Lairmore
Nov 12, 2015·Journal of Immunology Research·Carolina Rosadas, Marzia Puccioni-Sohler
Jul 5, 2002·Journal of Virology·Laurent LefèbvreRichard Kettmann
Apr 5, 2018·Frontiers in Microbiology·Anurag Kulkarni, Charles R M Bangham
Dec 20, 2019·Retrovirology·Ramona MolesGenoveffa Franchini
Dec 20, 2019·Retrovirology·Sarkis SarkisCynthia A Pise-Masison

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