PMID: 9174643Jan 1, 1997Paper

Human T-cell lymphotropic virus tax and Epstein-Barr virus DNA in peripheral blood of multiple sclerosis patients during acute attack

Acta Neurologica Scandinavica. Supplementum
P FerranteD Caputo

Abstract

A study was performed to determine whether persistent or latent viruses are reactivated during the acute attack in relapsing remitting multiple sclerosis (MS). DNA of herpes simplex virus type 1 and 2 (HSV-1 and -2), human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), JC virus (JCV) and HTLV-I was searched, using nested polymerase chain reaction (PCR), in peripheral blood mononuclear cells (PBMCs) collected from 14 MS patients on the first day and, twice a week, during an acute attack of the disease. Viral DNA was detected, in at least one PBMC sample, in all the patients. Interestingly, EBV DNA was found in 42.8% of the patients on the first day, while a sharp increase of the HTLV tax-rex DNA frequency (35.7%) was observed on the tenth day. In MS relapse EBV DNA detection is an early, frequent event, while the finding of tax-rex, but not of other HTLV-I genomic regions, is a secondary phenomenon, suggesting that these two factors could interact in the pathogenesis of MS relapses.

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Citations

Apr 21, 2005·The Journal of Clinical Investigation·Sabine CepokBernhard Hemmer
Dec 17, 2014·Clinical & Translational Immunology·Michael P Pender, Scott R Burrows
May 6, 2015·Acta Neurologica Scandinavica·L B LathamJ W Lindsey
Oct 11, 2008·Multiple Sclerosis : Clinical and Laboratory Research·J W LindseyS Patel
Dec 21, 2006·Journal of Medical Virology·Roberta MancusoPasquale Ferrante
Nov 11, 1999·Current Opinion in Neurology·O Stüve, S S Zamvil
Jan 14, 2005·Journal of Medical Virology·Elisa BorghiPasquale Ferrante

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