PMID: 8995639Feb 1, 1997Paper

Human T-cell lymphotropic virus type 1 (HTLV-1)-induced syncytium formation mediated by vascular cell adhesion molecule-1: evidence for involvement of cell adhesion molecules in HTLV-1 biology

Journal of Virology
J E HildrethR A Hampton

Abstract

While studying the potential role of vascular cell adhesion molecule-1 (VCAM-1) in infection of endothelial cells by human immunodeficiency virus (HIV), we found that VCAM-1 can mediate human T-cell lymphotropic virus type 1 (HTLV-1)-induced syncytium formation. Both expression-vector-encoded and endogenously expressed VCAM-1 supported fusion of uninfected cells with HTLV-1-infected cells. Fusion was obtained with cell lines carrying the HTLV-1 genome and expressing viral proteins but not with an HTLV-1-transformed cell line that does not express viral proteins. In clones of VCAM-1-transfected cells, the degree of syncytium formation observed directly reflected the level of VCAM-1 expression. Syncytium formation between HTLV-1-expressing cells and VCAM-1+ cells could be blocked with antiserum against HTLV-1 gp46 and with a monoclonal antibody (MAb) against VCAM-1. Fusion was not blocked by antiserum against HIV or a MAb against VLA-4, the physiological counter-receptor for VCAM-1. The results indicate that VCAM-1 can serve as an accessory molecule or potential coreceptor for HTLV-1-induced cell fusion and provide direct evidence of a role for cell adhesion molecules in the biology of HTLV-1.

References

Dec 1, 1992·Annals of Internal Medicine·A Gessain, O Gout
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P M HoffmanF W Ruscetti
Nov 11, 1992·AIDS Research and Human Retroviruses·I J KoralnikG Franchini
Apr 1, 1992·Journal of Virology·P WesterveltL Ratner
Mar 27, 1992·Science·J M BergelsonR W Finberg
Sep 11, 1991·Proceedings of the National Academy of Sciences of the United States of America·M I CybulskyT Collins
Mar 10, 1989·Cell·J M GreveA McClelland
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J E TomassiniR J Colonno
Apr 15, 1986·International Journal of Cancer. Journal International Du Cancer·K HiramatsuH Yoshikura
Jan 1, 1988·Annals of the New York Academy of Sciences·T SaidaM Hatanaka
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J A HoxieD B Cines
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H HoshinoT Sugimura
Apr 15, 1983·International Journal of Cancer. Journal International Du Cancer·P D MarkhamR C Gallo
Sep 15, 1983·International Journal of Cancer. Journal International Du Cancer·K NagyR A Weiss
Mar 1, 1995·The Journal of Cell Biology·R AlonT A Springer
May 1, 1995·Journal of Virology·S L KingJ M Bergelson
Dec 1, 1993·Baillière's Clinical Haematology·K Yamaguchi, K Takatsuki
Nov 1, 1993·AIDS Research and Human Retroviruses·R J Orentas, J E Hildreth

❮ Previous
Next ❯

Citations

Sep 26, 2000·Journal of Clinical Pathology·C R Bangham
Sep 13, 2005·Oncogene·Nicolas ManelMarc Sitbon
Aug 17, 2005·Journal of Virology·F MartinG W Moseley
Jul 1, 2010·Viruses·Mohamed Nejmeddine, Charles R M Bangham
Apr 5, 2000·Pathology Oncology Research : POR·J OngrádiM Bendinelli
Mar 24, 2016·Viruses·Christine Gross, Andrea K Thoma-Kress
Aug 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stephen J GouldJames E K Hildreth
Nov 24, 1999·The Journal of General Virology·M A Sommerfelt
Dec 23, 2020·International Journal of Molecular Sciences·Héloïse LeroySerge Benichou
Mar 21, 2021·Reviews in Medical Virology·Sanaz Ahmadi GhezeldashtSeyed Abdolrahim Rezaee
Feb 25, 1998·Biochemical and Biophysical Research Communications·N MaedaM Miwa
Mar 18, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J E HildrethN A Halsey
Feb 23, 2000·Virology·S R Trejo, L Ratner
Apr 23, 1999·Journal of Reproductive Immunology·J B Davidson, G C Douglas
Jun 5, 1999·Microbiology and Molecular Biology Reviews : MMBR·P Höllsberg
Nov 19, 2003·Cell·Nicolas ManelJean-Luc Battini
Jun 21, 2005·Virology·Marie-Eve ParéBenoit Barbeau
Feb 18, 2003·Science·Tadahiko IgakuraCharles R M Bangham
Mar 15, 2003·Science·David Derse, Gisela Heidecker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.