Human T-cell lymphotropic virus type II-associated myelopathy: clinical and immunologic profiles

Annals of Neurology
T J LehkyS Jacobson

Abstract

Human T-cell lymphotropic virus type II (HTLV-II) is endemic in several ethnic tribes and among intravenous drug users in metropolitan areas. Despite the presence of HTLV-II in these various populations, the association of HTLV-II with disease is sparse and mainly limited to isolated case reports. This study is an extension of an earlier description of an HTLV-II-infected patient with neurologic disease and presents the clinical and immunologic findings of 4 patients with HTLV-II seropositivity and spastic paraparesis. The patients are of African-American origin with 3 of the patients being of Amerindian descent. All of the patients are seronegative for the human immunodeficiency virus (HIV). The patients progressed to a nonambulatory state in less than 5 years. Magnetic resonance imaging studies obtained from 3 of the patients demonstrated white matter disease in the cerebrum and spinal cord. The cerebrospinal fluid and serum contained antibodies to HTLV-II. The presence of proviral HTLV-II was confirmed by polymerase chain reaction analysis of peripheral blood lymphocytes (PBLs). A spinal cord biopsy from 1 patient demonstrated HTLV RNA within a lesion. Immunologic studies on 2 patients demonstrated that spontaneous lymphopro...Continue Reading

References

Apr 1, 1992·Journal of Virology·W W HallR C Gallo
Jul 1, 1992·The Journal of Experimental Medicine·S IjichiW W Hall
Nov 7, 1992·Lancet·T FujinoY Nagata
Dec 1, 1992·Annals of Internal Medicine·A Gessain, O Gout
Feb 9, 1991·Lancet·S Z WiktorW A Blattner
Jan 1, 1991·Transfusion·T S Kickler
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M D LairmoreJ E Kaplan
Dec 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·A G KermodeW I McDonald
Apr 1, 1990·Journal of the Neurological Sciences·Y Iwasaki
May 3, 1986·Lancet·M OsameM Tara
Aug 7, 1986·The New England Journal of Medicine·J D RosenblattI S Chen
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M ShawF Wong-Staal
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Nov 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M H Kaplan
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T L WrightB F Scharschmidt
Mar 20, 1993·Lancet·E FeiginD Seror
Mar 20, 1993·Lancet·E L MurphyC G Hollingsworth
Aug 1, 1993·AIDS Research and Human Retroviruses·M P MartinD Mann
Feb 15, 1994·Annals of Internal Medicine·R B LalR A Gongora-Biachi
Sep 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·A YoshiokaK Sakai
Apr 1, 1993·Annals of Neurology·W J HarringtonB Poiesz

❮ Previous
Next ❯

Citations

Jun 17, 1999·Lancet·A MannsL La Grenade
Jan 1, 1997·Vox Sanguinis·H VrielinkH W Reesink
Aug 3, 2010·AIDS Research and Human Retroviruses·Ana TreviñoUNKNOWN HTLV Spanish Study Group
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Giovanna TosiRoberto S Accolla
Sep 4, 2014·Journal of Neurovirology·Carolina RosadasMarzia Puccioni-Sohler
Jan 1, 1997·Acta Neurologica Scandinavica. Supplementum·P Höllsberg
Dec 26, 2003·Journal of Medical Virology·Jürg BöniUNKNOWN Swiss HIV Cohort Study
Jan 10, 2002·Journal of Medical Virology·Edimilson A SilvaAna Carolina P Vicente
Feb 11, 2010·Revista clínica española·R Ramírez MontesinosC Richart Jurado
Mar 27, 2003·Neurosurgery·Aaron A Cohen-GadolWilliam E Krauss
Apr 11, 2017·Acta Pharmacologica Sinica·Lan-Lan ZhangJi-Long Chen
Feb 26, 2016·Revista Do Instituto De Medicina Tropical De São Paulo·Gregorio González-AlcaideVicent Soriano
Jul 6, 2004·Annals of Neurology·Abelardo Araujo, William W Hall
Jul 20, 2012·Continuum : Lifelong Learning in Neurology·Joseph R Berger
Nov 26, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gianguglielmo ZehenderMassimo Galli
May 20, 2021·Seminars in Neurology·Pria Anand

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Annals of Neurology
Abelardo Q-C Araújo, William W Hall
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Marcus Tulius SilvaMaria José Andrada-Serpa
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Mirna M BiglioneMaría I Berría
© 2021 Meta ULC. All rights reserved