Human T-cell lymphotropic/leukemia virus type 1 (HTLV-1) Tax-specific T-cell exhaustion in HTLV-1-infected individuals

Cancer Science
Ayako MasakiShinsuke Iida

Abstract

Adult T-cell leukemia/lymphoma (ATL) is caused by Human T-cell lymphotropic/leukemia virus type 1 (HTLV-1), and a higher HTLV-1 provirus load in PBMC is a risk factor for ATL development. Here, we document a significant inverse correlation between the function of HTLV-1 Tax-specific CTL (Tax-CTL), as assessed by ex vivo cytokine production in response to cognate peptide, and the HTLV-1 provirus load in PBMC in both HTLV-1 asymptomatic carriers (AC) (Spearman rank correlation coefficient [Rs] = -0.494, P = .037, n = 18) and ATL patients (Rs = -0.774, P = .001, n = 15). There was also a significant correlation between the HTLV-1 provirus load and the percentage of PD-1-positive Tax-CTL in both HTLV-1 AC (Rs = 0.574, P = .013) and ATL patients (Rs = 0.676, P = .006). Furthermore, the percentage of PD-1-positive Tax-CTL was inversely correlated with their function in HTLV-1 AC (Rs = -0.542, P = .020), and ATL patients (Rs = -0.639, P = .010). These findings indicate that the function of Tax-CTL decreased as their programmed cell death protein 1 (PD-1) levels increased, parallel to the increased HTLV-1 provirus load in PBMC. We propose that functional Tax-CTL are crucial for determining the HTLV-1 provirus load in PBMC, not only in ...Continue Reading

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Citations

Dec 29, 2019·Immunological Reviews·Craig FenwickGiuseppe Pantaleo
Sep 26, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kyohei YamadaKoichi Ohshima
Dec 20, 2018·Viruses·Nicolas FutschHélène Dutartre
Aug 15, 2020·Frontiers in Microbiology·Debora LevyJuliana Pereira
Jun 22, 2021·International Immunopharmacology·Mohammad Jalili-NikSeyed Isaac Hashemy

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Methods Mentioned

BETA
blood draw
genotyping

Software Mentioned

SPSS Statistics
FlowJo

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