PMID: 6169673Jan 1, 1981Paper

Human T cell proteins recognized by rabbit heteroantisera and monoclonal antibodies

International Journal of Immunopharmacology
T CotnerJ L Strominger

Abstract

Many structural and functional features of the cell surface antigens of human T cells remain to be characterized. In these investigations, heteroantisera have been used to identify potentially interesting antigens not yet recognized by individual monoclonal antibody preparations. These antigens include patterns of bands (Mr 140-240K) on various T cells and T cell lines, at least six other bands on T cell lines and novel antigens on CTL lines. The majority of these antigens are different from the compiled list of antigens recognized by monoclonal antibodies against T cell proteins. The monoclonal OKT9 recognizes an antigen most prevalent on dividing cells, and this antigen is the same as that recognized by another monoclonal antibody, 5E9, and by previously described heteroantisera. The monoclonal antibody 4F2 has a distribution similar to OKT9, but it is structurally distinct, and is also present on monocytes. Three T cell surface proteins, two defined by the monoclonal antibodies OKT6 and OKT10, recognize proteins which resemble HLA antigens physiochemically. OKT6 and NAI/34 both recognize a 49,000 glycoprotein which is associated with a 12,000 subunit which reacts with anti-beta 2-microglobulin antibodies. OKT10 recognizes a ...Continue Reading

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Citations

Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·J BerlingS von Kleist
May 1, 1988·Somatic Cell and Molecular Genetics·Y AkaoK Yamada
Oct 1, 1983·Molecular Immunology·C StähliC Kocyba
Oct 15, 1990·Cancer Genetics and Cytogenetics·H Ben-BassatM Prokocimer
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M E HemlerJ L Strominger
Feb 1, 1983·The Journal of Experimental Medicine·T CotnerJ Strominger
Mar 1, 1983·International Journal of Dermatology·P C KungR L Edelson
Jan 1, 1987·Leukemia Research·U R KeesR P Herrmann
Dec 1, 1983·Journal of Cutaneous Pathology·C L Berger, R L Edelson
Dec 1, 1983·Journal of Cutaneous Pathology·P C Kung
Jul 15, 1987·International Journal of Cancer. Journal International Du Cancer·S von KleistC Wittekind

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