PMID: 6167992Jun 1, 1981Paper

Human T cell surface antigens bearing a structural relationship to HLA antigens

Proceedings of the National Academy of Sciences of the United States of America
T CotnerJ L Strominger

Abstract

Three cell surface antigens that are structurally related to the human major histocompatibility antigens (called HLA antigens) have been characterized from the leukemic T cell line MOLT-4. One antigen is a glycoprotein of Mr 49,000 recognized by two monoclonal antibodies. OKT6 and NA1/34, and is associated with a Mr 12,000 subunit that crossreacts serologically with beta 2-microglobulin but can be distinguished from it by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. A second antigen, defined by the monoclonal antibody OKT10, is a Mr 46,000 protein associated with a small subunit distinct from beta 2-microglobulin. The OKT10 antigen is not restricted to T cells and is found on all T and B lymphoblastoid cell lines tested. The third protein is a beta 2-microglobulin-associated glycoprotein of Mr 43,000 that is serologically distinct from the OKT6 (NA1/34), OKT10, and HLA antigens. It is found on some, but not all, T cell lines but is absent from any other hematopoietic cell lines tested.

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Citations

Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·J BerlingS von Kleist
Jan 1, 1992·International Journal of Clinical & Laboratory Research·F MalavasiS Roggero
Mar 1, 1983·Journal of Reproductive Immunology·A R Sanderson, P J Ward
Mar 1, 1994·Immunology Today·F MalavasiK Mehta
Jan 1, 1983·Human Immunology·P G LerchC Terhorst
Mar 1, 1990·Human Immunology·J M Pesando, M A Stucki
Feb 1, 1992·Medical Hypotheses·B Daunter
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M MalissenB R Jordan
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H A ErlichD Pious
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L A Lampson, C A Fisher
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M E HemlerJ L Strominger
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M AmiotL Boumsell
Feb 1, 1983·The Journal of Experimental Medicine·T CotnerJ Strominger
Aug 1, 1984·The Journal of Experimental Medicine·M B BrennerJ L Strominger
Jan 1, 1981·International Journal of Immunopharmacology·T CotnerJ L Strominger
Nov 1, 1982·Cellular Immunology·P G NataliS Ferrone
Jan 1, 1988·Annals of the New York Academy of Sciences·B J LongleyR L Edelson
Dec 1, 1983·European Journal of Immunology·F KatzM Greaves
Jul 15, 1987·International Journal of Cancer. Journal International Du Cancer·S von KleistC Wittekind
Dec 22, 2016·Oncoimmunology·Djordje AtanackovicTim Luetkens

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