Human T-lymphocyte subpopulations in Hashimoto's disease

The Journal of Clinical Endocrinology and Metabolism
G W CanonicaG Giordano

Abstract

An inherited defect os suppressor T-lymphocytes has been hypothesized in Hashimoto's thyroiditis. To assess this hypothesis, human T-lymphocyte subsets (TG, T lymphocytes with surface receptors for the Fc fragment of immunoglobulin G; TM, T lymphocytes with Fc receptor for immunoglobulin M) have been studied in nine patients affected by the disease. To cells have been previously shown to be suppressors in the pokeweed mitogen-stimulated B-cell differentiation and have proved abnormal in several autoimmune or immunodeficiency disorders. The number of TG lymphocytes in the patients did not differ from that in normal controls. It is possible that 1) suppressor T-lymphocytes are not involved in the pathogenesis of Hashimoto's disease or 2) antigen-specific suppressor T-cells are involved, but too are low in number with respect to total TG.

Citations

Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Dec 9, 1982·The New England Journal of Medicine·C R StrakoschR Volpé
Apr 1, 1983·Journal of Endocrinological Investigation·M BagnascoO Ferrini
Jun 1, 1982·Clinical Immunology and Immunopathology·G W CanonicaG Giordano
May 1, 1984·Allergy·K BechH Nielsen
Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·S D FlynnS T Bigos
Feb 1, 1986·Australian and New Zealand Journal of Medicine·C R Strakosch
Feb 1, 1984·Journal of Endocrinological Investigation·W PruzanskiR Volpé
Apr 1, 1984·Journal of Endocrinological Investigation·P BiassoniM Bagnasco
Dec 1, 1984·Journal of Endocrinological Investigation·G W CanonicaM Bagnasco

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